Gastritis, nitrosamines and gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-03

AUTHORS

G. N. Stemmermann, H. Mower

ABSTRACT

Superficial gastritis accompanies peptic ulcer, gastroenterostomy, pernicious anemia, and exposure to nitrosamines. Once established, the process may be self perpetuating, resulting in atrophy, metaplasia, dysplasia and neoplasia. This can be explained, by the process of endogenous nitrosation of amines in the inflamed gastric mucosa. Evidence is presented that supports this hypothesis. Several drugs given parenterally have been identified as mutagenic nitroso compounds in homogenates of human and canine antral mucosa. Nitrite for this process is apparently derived from the inflamed mucosa. Different amines appear to be nitrosated at different places in the antrum suggesting the presence of sitespecific enzymes that control this reactions. More... »

PAGES

171-178

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02970315

DOI

http://dx.doi.org/10.1007/bf02970315

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042164383


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