Synthesis and anti-inflammatory testing of some new compounds incorporating 5-aminosalicylic acid (5-ASA) as potential prodrugs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-06

AUTHORS

Abdel-Alim Mohamed Abdel-Alim, Abdel-Nasser Ahmed El-Shorbagi, Samia Galal Abdel-Moty, Hajjaj Hassan Mohamed Abdel-Allah

ABSTRACT

This work includes the synthesis of 15 final compounds (6a-h and7b-h) as prodrugs of 5-ASA in the form of the acid itself, esters and amides linked by an amide linkage through a spacer to the endocyclic ring N of nicotinamide. Also, 15 new intermediate compounds were prepared. The target compounds (6b, 6f, 7b, and7e-h) revealed potent analgesic and anti-inflammatory activities in comparison to sulfasalazine and 5-ASA. In addition, ulcerogenicity, LD50,in vivo andin vitro metabolism of compound7f were determined. More... »

PAGES

637-647

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02969351

DOI

http://dx.doi.org/10.1007/bf02969351

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018976259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16042070


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