Ontology type: schema:ScholarlyArticle
1991-03
AUTHORSS. J. Tzartos, M. T. Cung, P. Demange, H. Loutrari, A. Mamalaki, M. Marraud, I. Papadouli, C. Sakarellos, V. Tsikaris
ABSTRACTMyasthenia gravis (MG) is caused by autoantibodies against the nicotinic acetylcholine receptor (AChR) of the neuromuscular junction. The anti-AChR antibodies are heterogeneous. However, a small region on the extracellular part of the AChR alpha subunit, called the main immunogenic region (MIR), seems to be the major target of the anti-AChR antibodies, but not of the specific T-cells, in experimental animals and possibly in MG patients. The major loop of the overlapping epitopes for all testable anti-MIR monoclonal antibodies (MAbs) was localized within residues 67-76 (WNPADYGGIK for Torpedo and WNPDDYGGVK for human AChR) of the alpha subunit. The N-terminal half of alpha 67-76 is the most critical, Asn68 and Asp71 being indispensable for binding. Yet anti-MIR antibodies are functionally and structurally quite heterogeneous. Anti-MIR MAbs do not affect channel gating, but they are very potent in mediating acceleration of AChR degradation (antigenic modulation) in cell cultures and in transferring experimental MG in animals. Fab fragments of anti-MIR MAbs bound to the AChR prevent the majority of the MG patients' antibodies from binding to and causing loss of the AChR. Whether this inhibition means that most MG antibodies bind on the same small region or is a result of broad steric/allosteric effects is under current investigation. More... »
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http://scigraph.springernature.com/pub.10.1007/bf02935610
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"type": "PropertyValue",
"value": [
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]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"1725702"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8900963"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf02935610"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1015458745"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf02935610",
"https://app.dimensions.ai/details/publication/pub.1015458745"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130811_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/BF02935610"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02935610'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02935610'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02935610'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02935610'
This table displays all metadata directly associated to this object as RDF triples.
658 TRIPLES
21 PREDICATES
201 URIs
45 LITERALS
33 BLANK NODES