Screening of microorganisms producing esterase for the production of (R)-β-Acetylmercaptoisobutyric acid from methyl (R,S)-β-acetylmercaptoisobutyrate View Full Text


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Article Info

DATE

2000-02

AUTHORS

Boyapati Gokul, Je-Hyuk Lee, Ki-Bang Song, T. Panda, Sang-Ki Rhee, Chul-Ho Kim

ABSTRACT

(R)-β-acetylmercaptoisobutyric acid (RAM), a chiral compound, is an important intermediate for the chemical synthesis of various antihypertensive and congestive heart failure drugs. Microorganisms capable of converting (R,S)-β-acetylmercaptoisobutyric acid ((R,S)-ester) to RAM were screened from soil microorganisms. A strain ofPseudomonas sp. 1001 screened from a soil sample was selected to be the best. Cells showed an activity of 540 U/mL from culture broth and the enzyme was thermostable up to 70°C. This strain could produce RAM asymmetrically from (R,S)-ester. More... »

PAGES

57

References to SciGraph publications

  • 1995-11-01. Synthesis of four chiral pharmaceutical intermediates by biocatalysis in JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY
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    http://scigraph.springernature.com/pub.10.1007/bf02932355

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    http://dx.doi.org/10.1007/bf02932355

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