Bioconversion of fumaric acid to succinic acid by recombinantE. coli View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-03

AUTHORS

Xiaohai Wang, C. S. Gong, George T. Tsao

ABSTRACT

Succinic acid was produced efficiently from fumaric acid by a recombinant E. coli strain DH5 alpha/pGC1002 containing multicopy fumarate reductase genes. The effects of initial fumaric acid and glucose concentration on the production of succinic acid were investigated. Succinic acid reached 41 to over 60 g/L in 48.5 h starting with 50 to 64 g/L fumaric acid. Significant substrate inhibition was observed at initial fumaric acid concentration of 90 g/L. L-Malic acid became the major fermentation product under these conditions. Provision of glucose (5-30 g/L) to the fermentation medium stimulated the initial succinic acid production rate over two folds. More... »

PAGES

919-928

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02920202

DOI

http://dx.doi.org/10.1007/bf02920202

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020502559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9627403


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