Ultrastructural study of hepatic granulomas induced byCryptococcus neoformans by quick-freezing and deep-etching method View Full Text


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Article Info

DATE

1993-12

AUTHORS

Nobuki Sakaguchi

ABSTRACT

The ultrastructure of hepatic granulomas induced by Cryptococcus (C.) neoformans was studied by a quick-freezing and deep-etching (QF-DE) method. Viable yeast cells were inoculated intravenously into rats and the livers were prepared for QF-DE replicas. Two cytoskeletal components were identified in the cytoplasm of macrophages composing the cryptococcal granulomas. These were: intermediate filaments, mainly located in the perinuclear region, and actin filaments, which were extensively decorated with myosin subfragment 1 (S1) and formed networks in the peripheral portion of the cytoplasm. In addition, two types of macrophage pseudopodia were observed in the granulomas. These were cobble stone-like pseudopodia at the yeast-macrophages contract areas, and thin, long and occasionally interdigitating pseudopodia in which actin filaments were consistently observed. Dense networks of actin filaments were also seen in pseudopodia protruding into the tight structure of the capsule of C. neoformans. These results suggest a role for actin filaments as one of the main factors in the force generating system of the phagocytic process. More... »

PAGES

57

References to SciGraph publications

  • 1990-03. Three-dimensional and histochemical studies of peroxisomes in cultured hepatocytes by quickfreezing and deep-etching method in JOURNAL OF MOLECULAR HISTOLOGY
  • 1985-11. Immunocytochemical study on the cytoplasmic side of cell membranes infected with vesicular stomatitis virus by quick-freezing and deep-etching replica method in HISTOCHEMISTRY AND CELL BIOLOGY
  • 1989-10. Ultrastructural and immunocytochemical studies on the cytoskeleton in the anterior pituitary of rats, with special regard to the relationship between actin filaments and secretory granules in CELL AND TISSUE RESEARCH
  • 1990-02. Twenty-five years with Cryptococcus neoformans in MYCOPATHOLOGIA
  • 1992-12. Three-dimensional study of the cytoskeleton in macrophages and multinucleate giant cells by quick-freezing and deep-etching method in VIRCHOWS ARCHIV B CELL PATHOLOGY
  • 1988-08. The microglial cytoskeleton: vimentin is localized within activated cellsin situ in BRAIN CELL BIOLOGY
  • 1980-01. Intermediate filaments as mechanical integrators of cellular space in NATURE
  • 1993-03. Ultrastructural study ofCryptococcus neoformans by quick-freezing and deep-etching method in MYCOPATHOLOGIA
  • 1988-10. Electron microscopic cytochemical analysis of hepatic granuloma induced by Cryptococcus neoformans in MYCOPATHOLOGIA
  • 1993-12. Three-dimensional study of epithelioid cells by a quick-freezing and deep-etching method in muramyl dipeptide-induced granulomas in VIRCHOWS ARCHIV B CELL PATHOLOGY
  • 1981-12. Cytoskeleton in Cells of the mononuclear phagocyte system in VIRCHOWS ARCHIV B CELL PATHOLOGY
  • 1974-09. The interaction of phagocytes and the large-sized parasite Cryptococcus neoformans: Cytochemical and ultrastructural study in CELL AND TISSUE RESEARCH
  • 1978-03. Intermediate filaments anchor the nuclei in nuclear monolayers of cultured human fibroblasts in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02915096

    DOI

    http://dx.doi.org/10.1007/bf02915096

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8401817


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