Immunohistochemical localization of chromostatin and pancreastatin, chromogranin A-Derived bioactive peptides, in normal and neoplastic neuroendocrine tissues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-02

AUTHORS

Noriko Kimura, Akihiro Funakoshi, Dominique Aunis, Kayoko Tateishi, Wakako Miura, Hiroshi Nagura

ABSTRACT

Despite the widespread distribution of chromogranin A (CgA) in neuroendocrine tissues, the biological function of CgA has not yet been elucidated. The primary amino acid sequence of CgA, elucidated by cDNA analysis, has been revealed to include several pairs of basic amino acid residues that are homologous to the bioactive peptides, such as pancreastatin (PST) and chromostatin (CST). Using antibodies for human PST and CST, the immunohistochemical localization of these peptides was investigated in neuroendocrine tissues, including human pituitary glands, pancreas, adrenal medulla, various types of neuroendocrine neoplasms (13 pheochromocytomas, 10 medullary thyroid carcinomas, 11 pancreatic endocrine tumors, and 19 carcinoid tumors), and the cell line QGP-1N derived from human somatostatin-producing pancreatic endocrine tumor.Variable immunoreactive intensities of PST and CST were seen, but both peptides were detectable in all neuroendocrine tissues and in most of the neoplasms. Immunoreactivity for both PST and CST was observed in 100 and 73%, respectively, of pancreatic endocrine tumors, all pheochromocytomas, and 80 and 40%, respectively, of medullary thyroid carcinomas, as well as all nonrectal carcinoid tumors. In rectal carcinoids, cells immunoreactive for PST and CST were sparse. The distribution of PST and CST was similar to that of CgA, and it is considered that these peptides are simultaneously processed from CgA, and may play roles in autocrine and paracrine regulation on various hormones in addition to their previously known functions. More... »

PAGES

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02914987

DOI

http://dx.doi.org/10.1007/bf02914987

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051984736

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12114688


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