Hemolysis after mitral valve replacement with mechanical valve prostheses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Mikio Ninomiya, Kuniyoshi Yagyu, Yukihiro Kaneko, Yutaka Kotsuka, Shinichi Takamoto

ABSTRACT

OBJECTIVE: We evaluated effects of type, size, and orientation of mechanical mitral valve prostheses on hemolysis. METHODS: Subjects were 84 patients who had undergone mitral valve replacement. Lactate dehydrogenase was mainly used as a marker of hemolysis and was measured before surgery, 1 month after surgery, and in the late postoperative period. RESULTS: Valves used included 16 Medtronic-Hall, 32 St. Jude Medical, and 36 CarboMedics valves. Medtronic-Hall valves caused less hemolysis than St. Jude Medical or CarboMedics valves in the late postoperative period. This resulted because hemolysis due to Medtronic-Hall valves was more severe 1 month after surgery than in the late postoperative period and because hemolysis due to St. Jude Medical or CarboMedics valves was more severe in the late postoperative period than 1 month after surgery. One reason for this finding is that cardiac output was greater in the late postoperative period than 1 month after surgery, making regurgitation through the pivots of bileaflet valves more severe. The orifice area and the orientation of prostheses did not affect hemolysis. CONCLUSION: St. Jude Medical or CarboMedics valves caused more severe hemolysis than Medtronic-Hall valves in the late postoperative period. More... »

PAGES

230-235

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02913521

DOI

http://dx.doi.org/10.1007/bf02913521

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022777398

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11355256


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