Sleep deprivation hastens the antidepressant action of fluoxetine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04

AUTHORS

F. Benedetti, B. Barbini, A. Lucca, E. Campori, C. Colombo, E. Smeraldi

ABSTRACT

Among ten bipolar depressed patients admitted to our psychiatric ward, five patients were treated with fluoxetine alone and five subjects were treated with fluoxetine in association with total sleep deprivation (TSD) in order to evaluate the effect of the interaction between the administration of the serotonergic antidepressant compound fluoxetine and repeated cycles of TSD. Patients treated with fluoxetine plus repeated TSD showed a faster amelioration of depressive symptomatology compared with the other group. We discuss our findings hypothesizing an enhancement in dopaminergic and possibly in serotonergic transmission due to repeated TSD adding to the increase in serotonergic transmission due to fluoxetine medication. More... »

PAGES

100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02900200

DOI

http://dx.doi.org/10.1007/bf02900200

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000762131

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9177956


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