Immunohistochemical characterization, distribution and ultrastructure of lymphocytes bearing the gamma/delta T-cell receptor in the human gut View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-12

AUTHORS

Kouhei Fukushima, Takayuki Masuda, Haruo Ohtani, Iwao Sasaki, Yuji Funayama, Seiki Matsuno, Hiroshi Nagura

ABSTRACT

The phenotypic characterization and distribution of lymphocytes bearing the gamma/delta T-cell receptor (TCR) in the human gut were investigated by an immunohistochemical technique. A mirror section technique and double staining method were used for the phenotypic analysis. Intraepithelial delta-positive cells were almost all CD8-positive and rarely negative for both CD4 and CD8. On the other hand, lymphocytes bearing TCR gamma/delta in the lamina propria were largely negative for both CD4 and CD8. The ratio of delta-positive to CD3-positive cells amongst intraepithelial lymphocytes was larger in the lower intestine. Deltapositive cells were also observed in paracortical areas of lymphoid follicles. Immunoelectron microscopic observation revealed granular structures in these delta-positive cells, which are also present in large granular lymphocytes. The role of lymphocytes bearing TCR gamma/ delta in mucosal immune responses in the human gut are discussed. More... »

PAGES

7

References to SciGraph publications

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  • 1985-02. Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes in NATURE
  • 1988-06. Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes in NATURE
  • 1986-07. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes in NATURE
  • 1984-06. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences in NATURE
  • 1987-02. A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes in NATURE
  • 1983-01. A lymphoproliferative disorder of the large granular lymphocytes with natural killer activity in JOURNAL OF CLINICAL IMMUNOLOGY
  • 1986-07. Hepatic vascular endothelial cells heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02899521

    DOI

    http://dx.doi.org/10.1007/bf02899521

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000819341

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1673280


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