Mice lacking protein tyrosine kinase fyn develop a T helper-type 1 response and resistLeishmania major infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-07

AUTHORS

Kazuo Yamakami, Shinkichi Akao, Kazuo Wakabayashi, Takushi Tadakuma, Nobuyuki Yoshizawa

ABSTRACT

Fyn is a Src family protein tyrosine kinase associated with TCR/CD3 complex. Fyn appears to play a role in the activation of T cells based on its enzymatic activation and tyrosine phosphorylation following the ligation of TCR/CD3, and it also plays a critical role in the calcium flux and interleukin-2 (IL-2) production. The protective response against murineLeishmania major infection is associated with the T helper-type 1 (Th1) responses and the ability to modulate Th1 cytokines such as IL-2 and interferon-γ, respectively. The role of Fyn tyrosine kinasein vivo was directly examined by the response to infection withL. major in C57BL/6fyn-deficient mice. Despite the absence of Fyn, the mice remained resistant to this infection with only mild lesion development, and, they demonstrated Th1 responses as assessed by the delayed-type hyper-sensitivity response and cytokine milieu. The findings in thefyn-deficient mice failed to support a relationship between the anticipated functions of Fynin vitro and the immune response toL. major infectionin vivo. As a result, in leishmanial disease, Fyn probably plays a minor role in the protective immune response and is, therefore, not a key factor in such a response. More... »

PAGES

132-135

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02897960

DOI

http://dx.doi.org/10.1007/bf02897960

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030206692

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21432251


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