The effect of route of administration and fractionation of dose on the metabolism of ifosfamide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

M. J. Lind, H. L. Roberts, N. Thatcher, J. R. Idle

ABSTRACT

The measurement of urinary ifosfamide, isophosphoramide mustard, dechloroethyl ifosfamide and carboxyifosfamide using high-performance thin-layer chromatography with photographic densitometry (TLC-PD) is described. This technique was also used to demonstrate the large inter-individual variation in the ifosfamide metabolic profile of patients receiving the drug as single-agent therapy for non-small-cell lung cancer. In addition, oral administration was shown to result in higher levels of these metabolites in the urine. Fractionation of the ifosfamide dose over several days resulted in increasing levels of metabolites in the urine, consistent with auto-induction of ifosfamide metabolism. More... »

PAGES

105

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02897254

DOI

http://dx.doi.org/10.1007/bf02897254

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025642415

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2347037


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