Use of mutagens in the improvement of production strains of microorganisms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1971-05

AUTHORS

R. W. Thoma

ABSTRACT

Physical and chemical agents were employed in our laboratories to induce mutation in a variety of microorganisms used for production of antibioties or enzymes. Improved production strains ofPenicillium chrysogenum (penicillin-producer),Streptomyces griseus (streptomycin-producer),Streptomyces nodosus. (amphotericin B-producer),Streptomyces noursei (nystatin-producer),Streptomyces umbrinus (diumycin-producer),Streptomyces prasinus (prasinomycin-producer),Streptomyces roseochromogenes (steroid-16α-hydroxylase-producer), andArthrobacter simplex (steroid-1-dehydrogenase-producer) were developed by use of mutation selection techniques. The methods found to be most successful with each species are described. The genealogical relationships within species of a number of strains ofPenicillium chrysogenum, Streptomyces prasinus, andStreptomyces roseochromogenes are presented. More... »

PAGES

197-204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02884208

DOI

http://dx.doi.org/10.1007/bf02884208

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044399790

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4998300


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acridines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acyltransferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alkylating Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthrobacter", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacillus megaterium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetics, Microbial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mixed Function Oxygenases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutagens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Penicillins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Penicillium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Purines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrimidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Effects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptomyces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultraviolet Rays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Squibb Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.416248.d", 
          "name": [
            "The Squibb Institute for Medical Research, New Brunswick, New Jersey, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thoma", 
        "givenName": "R. W.", 
        "id": "sg:person.072427505.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.072427505.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0065-2164(08)70171-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011623706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2660(08)60115-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014779019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6603(08)60232-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016926664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2164(08)70491-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037230474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6603(08)60311-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043203542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470122723.ch6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044358076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.mi.23.100169.002415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044677149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2528497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069974283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080640968", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1971-05", 
    "datePublishedReg": "1971-05-01", 
    "description": "Physical and chemical agents were employed in our laboratories to induce mutation in a variety of microorganisms used for production of antibioties or enzymes. Improved production strains ofPenicillium chrysogenum (penicillin-producer),Streptomyces griseus (streptomycin-producer),Streptomyces nodosus. (amphotericin B-producer),Streptomyces noursei (nystatin-producer),Streptomyces umbrinus (diumycin-producer),Streptomyces prasinus (prasinomycin-producer),Streptomyces roseochromogenes (steroid-16\u03b1-hydroxylase-producer), andArthrobacter simplex (steroid-1-dehydrogenase-producer) were developed by use of mutation selection techniques. The methods found to be most successful with each species are described. The genealogical relationships within species of a number of strains ofPenicillium chrysogenum, Streptomyces prasinus, andStreptomyces roseochromogenes are presented.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf02884208", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1018001", 
        "issn": [
          "0015-5632", 
          "1874-9356"
        ], 
        "name": "Folia Microbiologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Use of mutagens in the improvement of production strains of microorganisms", 
    "pagination": "197-204", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d37e617b03520a79eb108806ee0d863aac2b1e38682886e814b047a40498e4aa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "4998300"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0376757"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02884208"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044399790"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02884208", 
      "https://app.dimensions.ai/details/publication/pub.1044399790"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130831_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF02884208"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02884208'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02884208'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02884208'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02884208'


 

This table displays all metadata directly associated to this object as RDF triples.

167 TRIPLES      21 PREDICATES      56 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02884208 schema:about N2e70dfcd234f4aa8851884c5e79f2702
2 N3a9ed307b8cb4378b84ff00f98b05318
3 N3f89b1114ef14ebd8527c8b6890a45cb
4 N4c5ea432c1414c6ebeea79676e3aebb9
5 N5bc7fe34ee1a4540a4f3a11dadb8273e
6 N5d9691303b7e4af79fbb97db3a967895
7 N5ffd0a3df05a4c94a57741c8bda5f6a8
8 N777d5399f605473fa551e88fa1cac41f
9 N7ab6c078b3484f27b8be3c5116fc9fda
10 N7c83c533f56a4d73b73f15fab1f39ea5
11 N805ce908be42497386668f9ff33839fe
12 N81e2e5d8664241be8c4e43fbc332a490
13 N8d067019b32247728219b80c86a5fce8
14 N9c49b735562c4944ad5d6539bb543bce
15 Nace53d50ab9b454eb1a68101dc957c48
16 Nf4b1a1c0bf474ce2bd00b7f471bb64ea
17 Nf4bada1febbc48d39ceb001c1eb542a1
18 Nfbd22ce053ef4bb793878d66bf4c37b7
19 anzsrc-for:06
20 anzsrc-for:0604
21 schema:author N9f6fd79fb8c24cbe9f6bf2e14d6fd1b8
22 schema:citation https://app.dimensions.ai/details/publication/pub.1080640968
23 https://doi.org/10.1002/9780470122723.ch6
24 https://doi.org/10.1016/s0065-2164(08)70171-0
25 https://doi.org/10.1016/s0065-2164(08)70491-x
26 https://doi.org/10.1016/s0065-2660(08)60115-7
27 https://doi.org/10.1016/s0079-6603(08)60232-9
28 https://doi.org/10.1016/s0079-6603(08)60311-6
29 https://doi.org/10.1146/annurev.mi.23.100169.002415
30 https://doi.org/10.2307/2528497
31 schema:datePublished 1971-05
32 schema:datePublishedReg 1971-05-01
33 schema:description Physical and chemical agents were employed in our laboratories to induce mutation in a variety of microorganisms used for production of antibioties or enzymes. Improved production strains ofPenicillium chrysogenum (penicillin-producer),Streptomyces griseus (streptomycin-producer),Streptomyces nodosus. (amphotericin B-producer),Streptomyces noursei (nystatin-producer),Streptomyces umbrinus (diumycin-producer),Streptomyces prasinus (prasinomycin-producer),Streptomyces roseochromogenes (steroid-16α-hydroxylase-producer), andArthrobacter simplex (steroid-1-dehydrogenase-producer) were developed by use of mutation selection techniques. The methods found to be most successful with each species are described. The genealogical relationships within species of a number of strains ofPenicillium chrysogenum, Streptomyces prasinus, andStreptomyces roseochromogenes are presented.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf Ne837beb9a6ad4ea39a6e3d54e9c638dc
38 Nf14a38905a7948f48253abec68035844
39 sg:journal.1018001
40 schema:name Use of mutagens in the improvement of production strains of microorganisms
41 schema:pagination 197-204
42 schema:productId N32f71421b8074d5d887ed17f6074bb75
43 Naed8de0ff3bd43a9a404385f9c0f9198
44 Ncbd6cd46f56547d19c746a38ca06ee70
45 Ndd868b1812524dcf87e2a427fde9d52c
46 Nf38470ecd9ba44a68d194fed25d38d71
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044399790
48 https://doi.org/10.1007/bf02884208
49 schema:sdDatePublished 2019-04-11T14:02
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher N1861ee3455454354b9a2d5f49122afc6
52 schema:url http://link.springer.com/10.1007/BF02884208
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N1861ee3455454354b9a2d5f49122afc6 schema:name Springer Nature - SN SciGraph project
57 rdf:type schema:Organization
58 N2e70dfcd234f4aa8851884c5e79f2702 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Mutagens
60 rdf:type schema:DefinedTerm
61 N32f71421b8074d5d887ed17f6074bb75 schema:name pubmed_id
62 schema:value 4998300
63 rdf:type schema:PropertyValue
64 N3a9ed307b8cb4378b84ff00f98b05318 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Alkylating Agents
66 rdf:type schema:DefinedTerm
67 N3f89b1114ef14ebd8527c8b6890a45cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Mutation
69 rdf:type schema:DefinedTerm
70 N4c5ea432c1414c6ebeea79676e3aebb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Arthrobacter
72 rdf:type schema:DefinedTerm
73 N5bc7fe34ee1a4540a4f3a11dadb8273e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Ultraviolet Rays
75 rdf:type schema:DefinedTerm
76 N5d9691303b7e4af79fbb97db3a967895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Genetics, Microbial
78 rdf:type schema:DefinedTerm
79 N5ffd0a3df05a4c94a57741c8bda5f6a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Streptomyces
81 rdf:type schema:DefinedTerm
82 N777d5399f605473fa551e88fa1cac41f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Species Specificity
84 rdf:type schema:DefinedTerm
85 N7ab6c078b3484f27b8be3c5116fc9fda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Anti-Bacterial Agents
87 rdf:type schema:DefinedTerm
88 N7c83c533f56a4d73b73f15fab1f39ea5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Acridines
90 rdf:type schema:DefinedTerm
91 N805ce908be42497386668f9ff33839fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Mixed Function Oxygenases
93 rdf:type schema:DefinedTerm
94 N81e2e5d8664241be8c4e43fbc332a490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Pyrimidines
96 rdf:type schema:DefinedTerm
97 N8d067019b32247728219b80c86a5fce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Radiation Effects
99 rdf:type schema:DefinedTerm
100 N9c49b735562c4944ad5d6539bb543bce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Purines
102 rdf:type schema:DefinedTerm
103 N9f6fd79fb8c24cbe9f6bf2e14d6fd1b8 rdf:first sg:person.072427505.70
104 rdf:rest rdf:nil
105 Nace53d50ab9b454eb1a68101dc957c48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Acyltransferases
107 rdf:type schema:DefinedTerm
108 Naed8de0ff3bd43a9a404385f9c0f9198 schema:name doi
109 schema:value 10.1007/bf02884208
110 rdf:type schema:PropertyValue
111 Ncbd6cd46f56547d19c746a38ca06ee70 schema:name readcube_id
112 schema:value d37e617b03520a79eb108806ee0d863aac2b1e38682886e814b047a40498e4aa
113 rdf:type schema:PropertyValue
114 Ndd868b1812524dcf87e2a427fde9d52c schema:name nlm_unique_id
115 schema:value 0376757
116 rdf:type schema:PropertyValue
117 Ne837beb9a6ad4ea39a6e3d54e9c638dc schema:volumeNumber 16
118 rdf:type schema:PublicationVolume
119 Nf14a38905a7948f48253abec68035844 schema:issueNumber 3
120 rdf:type schema:PublicationIssue
121 Nf38470ecd9ba44a68d194fed25d38d71 schema:name dimensions_id
122 schema:value pub.1044399790
123 rdf:type schema:PropertyValue
124 Nf4b1a1c0bf474ce2bd00b7f471bb64ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Penicillium
126 rdf:type schema:DefinedTerm
127 Nf4bada1febbc48d39ceb001c1eb542a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Penicillins
129 rdf:type schema:DefinedTerm
130 Nfbd22ce053ef4bb793878d66bf4c37b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Bacillus megaterium
132 rdf:type schema:DefinedTerm
133 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
134 schema:name Biological Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
137 schema:name Genetics
138 rdf:type schema:DefinedTerm
139 sg:journal.1018001 schema:issn 0015-5632
140 1874-9356
141 schema:name Folia Microbiologica
142 rdf:type schema:Periodical
143 sg:person.072427505.70 schema:affiliation https://www.grid.ac/institutes/grid.416248.d
144 schema:familyName Thoma
145 schema:givenName R. W.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.072427505.70
147 rdf:type schema:Person
148 https://app.dimensions.ai/details/publication/pub.1080640968 schema:CreativeWork
149 https://doi.org/10.1002/9780470122723.ch6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044358076
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/s0065-2164(08)70171-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011623706
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/s0065-2164(08)70491-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037230474
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/s0065-2660(08)60115-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014779019
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/s0079-6603(08)60232-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016926664
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/s0079-6603(08)60311-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043203542
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1146/annurev.mi.23.100169.002415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044677149
162 rdf:type schema:CreativeWork
163 https://doi.org/10.2307/2528497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069974283
164 rdf:type schema:CreativeWork
165 https://www.grid.ac/institutes/grid.416248.d schema:alternateName Squibb Institute for Medical Research
166 schema:name The Squibb Institute for Medical Research, New Brunswick, New Jersey, U.S.A.
167 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...