Antagonistic effect of FePP on the ethanol mediated induction of hepatic, renal and splenic δ-amino levulinic acid synthase activityin vivo ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-07

AUTHORS

Ramesh Chandra, Ritu Aneja, Charu Rewal, Swati Bhowmik, Sujata K. Dass, Ritu Jain

ABSTRACT

In the current study, we report perturbations in hepatic, renal and splenic heme synthesis at the level of the rate limiting enzyme, δ-amino levulinic acid synthase (ALA-S) on ethanol administration independently and in conjunction with iron-protoporphyrin (FePP) in male Wistar rats. Excessive ethanol administration (5 ml/kg bw) resulted in a significant induction of hepatic, splenic and renal ALA-S activity. Simultaneous administration of FePP (50 μmol/kg bw) reverted the observed induction response to a sharp decline. The features of the action of ethanol and FePP togetherin vivo, i.e. a substantial inhibition of ALA-S is suggestive of the beneficial effects of this formulation in acute attacks of porphyria. More... »

PAGES

141-147

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02883743

DOI

http://dx.doi.org/10.1007/bf02883743

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000730988

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23105256


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