Ontology type: schema:ScholarlyArticle Open Access: True
2000-07
AUTHORSRamesh Chandra, Ritu Aneja, Charu Rewal, Swati Bhowmik, Sujata K. Dass, Ritu Jain
ABSTRACTIn the current study, we report perturbations in hepatic, renal and splenic heme synthesis at the level of the rate limiting enzyme, δ-amino levulinic acid synthase (ALA-S) on ethanol administration independently and in conjunction with iron-protoporphyrin (FePP) in male Wistar rats. Excessive ethanol administration (5 ml/kg bw) resulted in a significant induction of hepatic, splenic and renal ALA-S activity. Simultaneous administration of FePP (50 μmol/kg bw) reverted the observed induction response to a sharp decline. The features of the action of ethanol and FePP togetherin vivo, i.e. a substantial inhibition of ALA-S is suggestive of the beneficial effects of this formulation in acute attacks of porphyria. More... »
PAGES141-147
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DOIhttp://dx.doi.org/10.1007/bf02883743
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23105256
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