Artificial gravity loading increases the effects of the glutamate transporter inhibitors on the glutamate release and uptake in rat brain ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-09

AUTHORS

Tatiana Borisova, Natalia Krisanova, Nina Himmelreich

ABSTRACT

The present study evaluated the effect of artificial gravity loading on transporter-mediated uptake and release of L-glutamate using the inhibitors of glutamate transporters as tools. The competitive nontransportable, DL-threo-beta-benzyloxyaspartate (DL-TBOA), and transportable, DL-threo-beta-hydroxyaspartate (DL-THA), inhibitors were demonstrated to better inhibit the L-[14C]glutamate uptake under centrifuge-induced hypergravity compared with the normal gravity control. The effect of DL-TBOA on depolarization-induced carrier-mediated L-[14C]glutamate release also increased after hypergravity loading in Na+- and low [Na+] NMDG- supplemented media. 10 µM DL-TBOA-induced decrease in L-[14C]glutamate release in Na+ — supplemented medium was 15.2±2.2 % in the control experiments and 26.2±3.9 % after centrifuge-induced loading (P≤0,05) and in low [Na+] medium was 37.0±2.5 % and 45.0±3.4 %, respectively. More... »

PAGES

230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02870416

DOI

http://dx.doi.org/10.1007/bf02870416

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047113270


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Physical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev", 
          "id": "http://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borisova", 
        "givenName": "Tatiana", 
        "id": "sg:person.01230104173.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230104173.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev", 
          "id": "http://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krisanova", 
        "givenName": "Natalia", 
        "id": "sg:person.0105352300.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105352300.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev", 
          "id": "http://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Himmelreich", 
        "givenName": "Nina", 
        "id": "sg:person.01016527735.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016527735.99"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2006-09", 
    "datePublishedReg": "2006-09-01", 
    "description": "The present study evaluated the effect of artificial gravity loading on transporter-mediated uptake and release of L-glutamate using the inhibitors of glutamate transporters as tools. The competitive nontransportable, DL-threo-beta-benzyloxyaspartate (DL-TBOA), and transportable, DL-threo-beta-hydroxyaspartate (DL-THA), inhibitors were demonstrated to better inhibit the L-[14C]glutamate uptake under centrifuge-induced hypergravity compared with the normal gravity control. The effect of DL-TBOA on depolarization-induced carrier-mediated L-[14C]glutamate release also increased after hypergravity loading in Na+- and low [Na+] NMDG- supplemented media. 10 \u00b5M DL-TBOA-induced decrease in L-[14C]glutamate release in Na+ \u2014 supplemented medium was 15.2\u00b12.2 % in the control experiments and 26.2\u00b13.9 % after centrifuge-induced loading (P\u22640,05) and in low [Na+] medium was 37.0\u00b12.5 % and 45.0\u00b13.4 %, respectively.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf02870416", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1026232", 
        "issn": [
          "0938-0108", 
          "1875-0494"
        ], 
        "name": "Microgravity Science and Technology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3-4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "DL-TBOA", 
      "centrifuge-induced hypergravity", 
      "glutamate transporter inhibitor", 
      "rat brain nerve terminals", 
      "brain nerve terminals", 
      "glutamate release", 
      "transporter-mediated uptake", 
      "nerve terminals", 
      "glutamate transporters", 
      "hypergravity loading", 
      "transporter inhibitors", 
      "dl", 
      "present study", 
      "inhibitors", 
      "release", 
      "normal gravity controls", 
      "uptake", 
      "glutamate", 
      "effect", 
      "NMDG", 
      "control experiments", 
      "hypergravity", 
      "transporters", 
      "decrease", 
      "control", 
      "study", 
      "lower medium", 
      "terminals", 
      "gravity control", 
      "medium", 
      "tool", 
      "transportable", 
      "loading", 
      "experiments", 
      "gravity loading", 
      "artificial gravity loading", 
      "low [Na+] NMDG", 
      "centrifuge-induced loading"
    ], 
    "name": "Artificial gravity loading increases the effects of the glutamate transporter inhibitors on the glutamate release and uptake in rat brain nerve terminals", 
    "pagination": "230", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047113270"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02870416"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02870416", 
      "https://app.dimensions.ai/details/publication/pub.1047113270"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf02870416"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02870416'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02870416'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02870416'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02870416'


 

This table displays all metadata directly associated to this object as RDF triples.

110 TRIPLES      21 PREDICATES      64 URIs      56 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02870416 schema:about anzsrc-for:02
2 anzsrc-for:0299
3 schema:author N5d43f7e68422465b8134b702a41251ef
4 schema:datePublished 2006-09
5 schema:datePublishedReg 2006-09-01
6 schema:description The present study evaluated the effect of artificial gravity loading on transporter-mediated uptake and release of L-glutamate using the inhibitors of glutamate transporters as tools. The competitive nontransportable, DL-threo-beta-benzyloxyaspartate (DL-TBOA), and transportable, DL-threo-beta-hydroxyaspartate (DL-THA), inhibitors were demonstrated to better inhibit the L-[14C]glutamate uptake under centrifuge-induced hypergravity compared with the normal gravity control. The effect of DL-TBOA on depolarization-induced carrier-mediated L-[14C]glutamate release also increased after hypergravity loading in Na+- and low [Na+] NMDG- supplemented media. 10 µM DL-TBOA-induced decrease in L-[14C]glutamate release in Na+ — supplemented medium was 15.2±2.2 % in the control experiments and 26.2±3.9 % after centrifuge-induced loading (P≤0,05) and in low [Na+] medium was 37.0±2.5 % and 45.0±3.4 %, respectively.
7 schema:genre article
8 schema:inLanguage en
9 schema:isAccessibleForFree false
10 schema:isPartOf N8ffde37b7f9f44f596e0fab27080cea1
11 Nd11101184ca949ae91d1e440e781ba79
12 sg:journal.1026232
13 schema:keywords DL-TBOA
14 NMDG
15 artificial gravity loading
16 brain nerve terminals
17 centrifuge-induced hypergravity
18 centrifuge-induced loading
19 control
20 control experiments
21 decrease
22 dl
23 effect
24 experiments
25 glutamate
26 glutamate release
27 glutamate transporter inhibitor
28 glutamate transporters
29 gravity control
30 gravity loading
31 hypergravity
32 hypergravity loading
33 inhibitors
34 loading
35 low [Na+] NMDG
36 lower medium
37 medium
38 nerve terminals
39 normal gravity controls
40 present study
41 rat brain nerve terminals
42 release
43 study
44 terminals
45 tool
46 transportable
47 transporter inhibitors
48 transporter-mediated uptake
49 transporters
50 uptake
51 schema:name Artificial gravity loading increases the effects of the glutamate transporter inhibitors on the glutamate release and uptake in rat brain nerve terminals
52 schema:pagination 230
53 schema:productId Ndc742390fd314e6cbb97eb7363160dcf
54 Ne2aaba0a04d745288e2834e8a915b335
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047113270
56 https://doi.org/10.1007/bf02870416
57 schema:sdDatePublished 2021-12-01T19:17
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N6e3755f164d4459b969098efb69d1bc6
60 schema:url https://doi.org/10.1007/bf02870416
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N41a56c34d7174917a0f5fbf63809aab7 rdf:first sg:person.0105352300.44
65 rdf:rest Nf5d295d6a6ad43a98958e0272ef21cce
66 N5d43f7e68422465b8134b702a41251ef rdf:first sg:person.01230104173.60
67 rdf:rest N41a56c34d7174917a0f5fbf63809aab7
68 N6e3755f164d4459b969098efb69d1bc6 schema:name Springer Nature - SN SciGraph project
69 rdf:type schema:Organization
70 N8ffde37b7f9f44f596e0fab27080cea1 schema:issueNumber 3-4
71 rdf:type schema:PublicationIssue
72 Nd11101184ca949ae91d1e440e781ba79 schema:volumeNumber 18
73 rdf:type schema:PublicationVolume
74 Ndc742390fd314e6cbb97eb7363160dcf schema:name dimensions_id
75 schema:value pub.1047113270
76 rdf:type schema:PropertyValue
77 Ne2aaba0a04d745288e2834e8a915b335 schema:name doi
78 schema:value 10.1007/bf02870416
79 rdf:type schema:PropertyValue
80 Nf5d295d6a6ad43a98958e0272ef21cce rdf:first sg:person.01016527735.99
81 rdf:rest rdf:nil
82 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
83 schema:name Physical Sciences
84 rdf:type schema:DefinedTerm
85 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
86 schema:name Other Physical Sciences
87 rdf:type schema:DefinedTerm
88 sg:journal.1026232 schema:issn 0938-0108
89 1875-0494
90 schema:name Microgravity Science and Technology
91 schema:publisher Springer Nature
92 rdf:type schema:Periodical
93 sg:person.01016527735.99 schema:affiliation grid-institutes:grid.419966.5
94 schema:familyName Himmelreich
95 schema:givenName Nina
96 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016527735.99
97 rdf:type schema:Person
98 sg:person.0105352300.44 schema:affiliation grid-institutes:grid.419966.5
99 schema:familyName Krisanova
100 schema:givenName Natalia
101 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105352300.44
102 rdf:type schema:Person
103 sg:person.01230104173.60 schema:affiliation grid-institutes:grid.419966.5
104 schema:familyName Borisova
105 schema:givenName Tatiana
106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230104173.60
107 rdf:type schema:Person
108 grid-institutes:grid.419966.5 schema:alternateName Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev
109 schema:name Department of Neurochemistry, Palladin Institute of Biochemistry KAS of Ukraine, Kiev
110 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...