Anti-inflammatory activity of clarithromycin in adults with chronically inflamed sinus mucosa View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Catherine M. MacLeod, Qutayba A. Hamid, Lisa Cameron, Chantal Tremblay, Wygenia Brisco

ABSTRACT

In a phase IV, open-label study, 25 patients with clinically stable chronic sinusitis and persistent maxillary sinus inflammation were treated for 14 days with clarithromycin 500 mg twice daily. Biopsy specimens of the maxillary sinus mucosa were obtained pretreatment and evaluated for macrophages (CD68), eosinophils (MBP), elastase, interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha (TNF-alpha), and activity of eosinophils (EG2), as well as edema score. Clinical signs and symptoms were assessed pretreatment, at the end of treatment, and 1 and 2 weeks later. Statistically significant reductions (P < or = .05) from pretreatment were observed for all markers of sinus mucosal inflammation, including CD68, EG2, elastase, IL-6, IL-8, TNF-alpha, and edema score, with a trend to decreased total eosinophil count. Improvement was observed for all clinical signs and symptoms of chronic sinusitis--sinus pain, sinus headache, nasal congestion, nasal discharge, and mucopurulent discharge--up to 14 days after the end of treatment. Cultures to evaluate persistent infection with Chlamydia pneumoniae showed negative results. Significant reductions in various markers of sinus mucosal inflammation support the role of clarithromycin in modulating immunologic responses. Improvement of clinical signs and symptoms in patients with chronic inflammatory sinusitis not meeting criteria for known or presumed bacterial infection was also noted up to 2 weeks after completion of a 14-day course of clarithromycin. More... »

PAGES

75-82

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02852391

DOI

http://dx.doi.org/10.1007/bf02852391

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045940378

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11446271


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clarithromycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eosinophils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maxillary Sinus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maxillary Sinusitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mucous Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Abbott (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417574.4", 
          "name": [
            "Abbott Laboratories, Chicago, Illinois"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MacLeod", 
        "givenName": "Catherine M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "McGill University, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamid", 
        "givenName": "Qutayba A.", 
        "id": "sg:person.016215742657.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016215742657.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "McGill University, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cameron", 
        "givenName": "Lisa", 
        "id": "sg:person.01265454672.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265454672.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Novabyss Incorporated, Sherbrooke, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tremblay", 
        "givenName": "Chantal", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Abbott (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417574.4", 
          "name": [
            "Abbott Laboratories, Chicago, Illinois"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brisco", 
        "givenName": "Wygenia", 
        "id": "sg:person.01022620207.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022620207.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/jac/41.5.505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010329103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1529-0131(199908)42:8<1691::aid-anr18>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014715376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.38.11.2643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015517921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/1120009x.1993.11739237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025131282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(98)00046-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025280665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0924-8579(98)00091-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030203303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199957030-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037804927", 
          "https://doi.org/10.2165/00003495-199957030-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/27.suppl_a.61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059733066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.40.6.1366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082927798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083029833", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-03", 
    "datePublishedReg": "2001-03-01", 
    "description": "In a phase IV, open-label study, 25 patients with clinically stable chronic sinusitis and persistent maxillary sinus inflammation were treated for 14 days with clarithromycin 500 mg twice daily. Biopsy specimens of the maxillary sinus mucosa were obtained pretreatment and evaluated for macrophages (CD68), eosinophils (MBP), elastase, interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha (TNF-alpha), and activity of eosinophils (EG2), as well as edema score. Clinical signs and symptoms were assessed pretreatment, at the end of treatment, and 1 and 2 weeks later. Statistically significant reductions (P < or = .05) from pretreatment were observed for all markers of sinus mucosal inflammation, including CD68, EG2, elastase, IL-6, IL-8, TNF-alpha, and edema score, with a trend to decreased total eosinophil count. Improvement was observed for all clinical signs and symptoms of chronic sinusitis--sinus pain, sinus headache, nasal congestion, nasal discharge, and mucopurulent discharge--up to 14 days after the end of treatment. Cultures to evaluate persistent infection with Chlamydia pneumoniae showed negative results. Significant reductions in various markers of sinus mucosal inflammation support the role of clarithromycin in modulating immunologic responses. Improvement of clinical signs and symptoms in patients with chronic inflammatory sinusitis not meeting criteria for known or presumed bacterial infection was also noted up to 2 weeks after completion of a 14-day course of clarithromycin.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf02852391", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096634", 
        "issn": [
          "0741-238X", 
          "1865-8652"
        ], 
        "name": "Advances in Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Anti-inflammatory activity of clarithromycin in adults with chronically inflamed sinus mucosa", 
    "pagination": "75-82", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dad588edc93ecb4f664986e30fc7a027cb1c9ade7b8f52c7a33b7835654df597"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11446271"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8611864"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02852391"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045940378"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02852391", 
      "https://app.dimensions.ai/details/publication/pub.1045940378"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130829_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF02852391"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02852391'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02852391'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02852391'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02852391'


 

This table displays all metadata directly associated to this object as RDF triples.

210 TRIPLES      21 PREDICATES      59 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02852391 schema:about N0258aca83335409d85c5556671c97147
2 N1c6ada674e9047ac8f576b9c422e7d6d
3 N219ddcdf06394b56830e88ef60bd5ff0
4 N2d41a97ea63f471a8c05ef085ea63cdf
5 N47f1da56460640b09b44753c49f3eb50
6 N5d7cc1c3ba994a28b6ec11738317f75a
7 N848c2f16c9954b20bcfe2aedd54ab465
8 N976b0e3970b74a7f87e067d128b76732
9 N9af3d46f8a564c9588acf072bb6aa8e6
10 Na5d61818fa4f4d1b8bb163c0c782fd8a
11 Nabd6a52d825b4faabf2deec7f15993f9
12 Nb58130e0914f4fb386d6e760a7003b17
13 Nb7e24ce4a76e43daa4ab9ac71685e81f
14 Nc4941604333a4893be2b3d5f6833c2bb
15 Nc73d6c07e99c429d8a56b0972fbd3aaa
16 Ncb1ea398cb254f07a4741293af666fde
17 Nd598ed9e97404514b4c494b8f6907822
18 Ndd25e634fcc04bcda865224b861c1c8b
19 Ne173f125e42c493f9c5b99e8e2c7b916
20 Nebacc6c3fcbc44c09c11c51eff70d949
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author N2564ea2725fa42a698a6a445ad906b95
24 schema:citation sg:pub.10.2165/00003495-199957030-00001
25 https://app.dimensions.ai/details/publication/pub.1083029833
26 https://doi.org/10.1002/1529-0131(199908)42:8<1691::aid-anr18>3.0.co;2-s
27 https://doi.org/10.1016/s0014-2999(98)00046-6
28 https://doi.org/10.1016/s0924-8579(98)00091-0
29 https://doi.org/10.1080/1120009x.1993.11739237
30 https://doi.org/10.1093/jac/27.suppl_a.61
31 https://doi.org/10.1093/jac/41.5.505
32 https://doi.org/10.1128/aac.38.11.2643
33 https://doi.org/10.1128/aac.40.6.1366
34 schema:datePublished 2001-03
35 schema:datePublishedReg 2001-03-01
36 schema:description In a phase IV, open-label study, 25 patients with clinically stable chronic sinusitis and persistent maxillary sinus inflammation were treated for 14 days with clarithromycin 500 mg twice daily. Biopsy specimens of the maxillary sinus mucosa were obtained pretreatment and evaluated for macrophages (CD68), eosinophils (MBP), elastase, interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha (TNF-alpha), and activity of eosinophils (EG2), as well as edema score. Clinical signs and symptoms were assessed pretreatment, at the end of treatment, and 1 and 2 weeks later. Statistically significant reductions (P < or = .05) from pretreatment were observed for all markers of sinus mucosal inflammation, including CD68, EG2, elastase, IL-6, IL-8, TNF-alpha, and edema score, with a trend to decreased total eosinophil count. Improvement was observed for all clinical signs and symptoms of chronic sinusitis--sinus pain, sinus headache, nasal congestion, nasal discharge, and mucopurulent discharge--up to 14 days after the end of treatment. Cultures to evaluate persistent infection with Chlamydia pneumoniae showed negative results. Significant reductions in various markers of sinus mucosal inflammation support the role of clarithromycin in modulating immunologic responses. Improvement of clinical signs and symptoms in patients with chronic inflammatory sinusitis not meeting criteria for known or presumed bacterial infection was also noted up to 2 weeks after completion of a 14-day course of clarithromycin.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf Ne1652aef95274587ae67c16771521253
41 Ne1f7f2240dc94fa182cda42f96313602
42 sg:journal.1096634
43 schema:name Anti-inflammatory activity of clarithromycin in adults with chronically inflamed sinus mucosa
44 schema:pagination 75-82
45 schema:productId N45c23ef99ad4463384b90f3a3269551f
46 N4a79c7f7dcdc439d850221b965f44c1f
47 N4f16bcea2e2c4719af87eba47894f1a1
48 Nb48908111f5c48c6893d5c5aab35f7e9
49 Neaa40b02f8bf42cfbc83cf5fed867745
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045940378
51 https://doi.org/10.1007/bf02852391
52 schema:sdDatePublished 2019-04-11T14:01
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N4519febd837443e0b6ee94b9816879b3
55 schema:url http://link.springer.com/10.1007%2FBF02852391
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N0258aca83335409d85c5556671c97147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Chronic Disease
61 rdf:type schema:DefinedTerm
62 N1c6ada674e9047ac8f576b9c422e7d6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Inflammation Mediators
64 rdf:type schema:DefinedTerm
65 N214342570eb9475e9620a9eeee777dca rdf:first Ndf11693d74dd4308a325d3b48c249b31
66 rdf:rest Ncc15f052ff4b4dc1960db89ad22cba3f
67 N219ddcdf06394b56830e88ef60bd5ff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Mucous Membrane
69 rdf:type schema:DefinedTerm
70 N2564ea2725fa42a698a6a445ad906b95 rdf:first Ndc47461c12754b61b76ac0a820af5cc9
71 rdf:rest N38daa2f619a744249e4b273ab4bc4ac7
72 N2d41a97ea63f471a8c05ef085ea63cdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Macrophages
74 rdf:type schema:DefinedTerm
75 N38daa2f619a744249e4b273ab4bc4ac7 rdf:first sg:person.016215742657.56
76 rdf:rest Nb7877be507c24d908a1f15429e31fe81
77 N4519febd837443e0b6ee94b9816879b3 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N45c23ef99ad4463384b90f3a3269551f schema:name dimensions_id
80 schema:value pub.1045940378
81 rdf:type schema:PropertyValue
82 N47f1da56460640b09b44753c49f3eb50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Tumor Necrosis Factor-alpha
84 rdf:type schema:DefinedTerm
85 N4a79c7f7dcdc439d850221b965f44c1f schema:name pubmed_id
86 schema:value 11446271
87 rdf:type schema:PropertyValue
88 N4f16bcea2e2c4719af87eba47894f1a1 schema:name nlm_unique_id
89 schema:value 8611864
90 rdf:type schema:PropertyValue
91 N5d7cc1c3ba994a28b6ec11738317f75a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Middle Aged
93 rdf:type schema:DefinedTerm
94 N848c2f16c9954b20bcfe2aedd54ab465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Humans
96 rdf:type schema:DefinedTerm
97 N976b0e3970b74a7f87e067d128b76732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Aged
99 rdf:type schema:DefinedTerm
100 N9af3d46f8a564c9588acf072bb6aa8e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Interleukin-6
102 rdf:type schema:DefinedTerm
103 Na5d61818fa4f4d1b8bb163c0c782fd8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Anti-Bacterial Agents
105 rdf:type schema:DefinedTerm
106 Nabd6a52d825b4faabf2deec7f15993f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Clarithromycin
108 rdf:type schema:DefinedTerm
109 Nb48908111f5c48c6893d5c5aab35f7e9 schema:name readcube_id
110 schema:value dad588edc93ecb4f664986e30fc7a027cb1c9ade7b8f52c7a33b7835654df597
111 rdf:type schema:PropertyValue
112 Nb58130e0914f4fb386d6e760a7003b17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Maxillary Sinus
114 rdf:type schema:DefinedTerm
115 Nb7877be507c24d908a1f15429e31fe81 rdf:first sg:person.01265454672.45
116 rdf:rest N214342570eb9475e9620a9eeee777dca
117 Nb7e24ce4a76e43daa4ab9ac71685e81f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adult
119 rdf:type schema:DefinedTerm
120 Nc4941604333a4893be2b3d5f6833c2bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Eosinophils
122 rdf:type schema:DefinedTerm
123 Nc73d6c07e99c429d8a56b0972fbd3aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Prospective Studies
125 rdf:type schema:DefinedTerm
126 Ncb1ea398cb254f07a4741293af666fde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Anti-Inflammatory Agents
128 rdf:type schema:DefinedTerm
129 Ncc15f052ff4b4dc1960db89ad22cba3f rdf:first sg:person.01022620207.18
130 rdf:rest rdf:nil
131 Nd598ed9e97404514b4c494b8f6907822 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Interleukin-8
133 rdf:type schema:DefinedTerm
134 Ndc47461c12754b61b76ac0a820af5cc9 schema:affiliation https://www.grid.ac/institutes/grid.417574.4
135 schema:familyName MacLeod
136 schema:givenName Catherine M.
137 rdf:type schema:Person
138 Ndd25e634fcc04bcda865224b861c1c8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Female
140 rdf:type schema:DefinedTerm
141 Ndf11693d74dd4308a325d3b48c249b31 schema:affiliation Ne644344943bd440080278faa6f02dd07
142 schema:familyName Tremblay
143 schema:givenName Chantal
144 rdf:type schema:Person
145 Ne1652aef95274587ae67c16771521253 schema:volumeNumber 18
146 rdf:type schema:PublicationVolume
147 Ne173f125e42c493f9c5b99e8e2c7b916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Maxillary Sinusitis
149 rdf:type schema:DefinedTerm
150 Ne1f7f2240dc94fa182cda42f96313602 schema:issueNumber 2
151 rdf:type schema:PublicationIssue
152 Ne644344943bd440080278faa6f02dd07 schema:name Novabyss Incorporated, Sherbrooke, Quebec, Canada
153 rdf:type schema:Organization
154 Neaa40b02f8bf42cfbc83cf5fed867745 schema:name doi
155 schema:value 10.1007/bf02852391
156 rdf:type schema:PropertyValue
157 Nebacc6c3fcbc44c09c11c51eff70d949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Male
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
164 schema:name Clinical Sciences
165 rdf:type schema:DefinedTerm
166 sg:journal.1096634 schema:issn 0741-238X
167 1865-8652
168 schema:name Advances in Therapy
169 rdf:type schema:Periodical
170 sg:person.01022620207.18 schema:affiliation https://www.grid.ac/institutes/grid.417574.4
171 schema:familyName Brisco
172 schema:givenName Wygenia
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022620207.18
174 rdf:type schema:Person
175 sg:person.01265454672.45 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
176 schema:familyName Cameron
177 schema:givenName Lisa
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265454672.45
179 rdf:type schema:Person
180 sg:person.016215742657.56 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
181 schema:familyName Hamid
182 schema:givenName Qutayba A.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016215742657.56
184 rdf:type schema:Person
185 sg:pub.10.2165/00003495-199957030-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037804927
186 https://doi.org/10.2165/00003495-199957030-00001
187 rdf:type schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1083029833 schema:CreativeWork
189 https://doi.org/10.1002/1529-0131(199908)42:8<1691::aid-anr18>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1014715376
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/s0014-2999(98)00046-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025280665
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0924-8579(98)00091-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030203303
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1080/1120009x.1993.11739237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025131282
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1093/jac/27.suppl_a.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059733066
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1093/jac/41.5.505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010329103
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1128/aac.38.11.2643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015517921
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1128/aac.40.6.1366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082927798
204 rdf:type schema:CreativeWork
205 https://www.grid.ac/institutes/grid.14709.3b schema:alternateName McGill University
206 schema:name McGill University, Montreal, Quebec, Canada
207 rdf:type schema:Organization
208 https://www.grid.ac/institutes/grid.417574.4 schema:alternateName Abbott (United States)
209 schema:name Abbott Laboratories, Chicago, Illinois
210 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...