Effect of the valine-threonine constraint on the dynamics of the proline helix — A molecular dynamics study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-04

AUTHORS

S. Shobana, Gautham Nadig, Saraswathi Vishveshwara

ABSTRACT

Proline residues in helices play an important role in the structure of proteins. The proline residue introduces a kink in the helix which varies from about 5° to 50°. The presence of other residues such as threonine or valine near the proline region can influence the flexibility exhibited by the kinked helix, which can have an important biological role. In the present paper, the constraint introduced by threonine and valine on a proline helix is investigated by molecular dynamics studies. The systems considered are (1) a poly-alanine helix with threonine-proline residues (TP) and (2) a poly-alanine helix with valine-threonineproline residues (VTP), in the middle. Molecular dynamics simulations are carried out on these two systems for500 ps. The results are analyzed in terms of structural transitions, bend-related parameters and sidechain orientations. More... »

PAGES

579-589

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02840772

DOI

http://dx.doi.org/10.1007/bf02840772

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086062046


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