The Znt4 mutation inlethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-03

AUTHORS

Chiara Murgia, Isabella Vespignani, Rita Rami, Giuditta Perozzi

ABSTRACT

The lethal milk mouse syndrome is caused by a point mutation in the zinc transporter gene ZnT4 resulting in defective zinc secretion in the milk of homozygous mutant dams. Pups of any genotype fed solely on lm milk die within the first two weeks of neonatal life, displaying zinc deficiency symptoms. Homozygous mutant pups survive when foster nursed by wild type dams and show signs of mild zinc deficiency in adulthood. To further investigate the role of ZnT4 in zinc secretion in the intestinal epithelium, we have studied the expression by real time quantitative PCR of mutant ZnT4 and of other zinc transporters of the Zip and ZnT families, in the jejunum of homozygous lm mice and of the isogenic wild type strain C57BL/ 6J. We report in this paper that expression of the mutant ZnT4 mRNA, carrying a premature translational termination codon (ZnT4/lm), is almost absent in tissues from lm mice, probably as a result of degradation by the Nonsense Mediated mRNA Decay (NMD) Pathway. In the jejunum of mutant mice, we also observed decreased expression of the uptake zinc transporter Zip4, paralleled by increased levels of both metallothionein genes MTI and MTII. Zinc supplementation of lm mice in the drinking water did not result in further decrease of Zip4 expression, but led to full induction of MT mRNAs. These results lead us to conclude that, although in the enterocytes of lm mice the absence of the zinc secretion activity mediated by ZnT4 results in increased intracellular zinc concentration, other zinc efflux activities are able to maintain the level of zinc ions below the threshold necessary for full induction of metallothioneins. More... »

PAGES

61-70

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02829937

DOI

http://dx.doi.org/10.1007/bf02829937

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020555297

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18850221


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione", 
          "id": "https://www.grid.ac/institutes/grid.419539.3", 
          "name": [
            "INRAN, National Research Institute on Food and Nutrition, via Ardeatina 546, 00178, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murgia", 
        "givenName": "Chiara", 
        "id": "sg:person.01134361174.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134361174.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione", 
          "id": "https://www.grid.ac/institutes/grid.419539.3", 
          "name": [
            "INRAN, National Research Institute on Food and Nutrition, via Ardeatina 546, 00178, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vespignani", 
        "givenName": "Isabella", 
        "id": "sg:person.01212356130.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212356130.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione", 
          "id": "https://www.grid.ac/institutes/grid.419539.3", 
          "name": [
            "INRAN, National Research Institute on Food and Nutrition, via Ardeatina 546, 00178, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rami", 
        "givenName": "Rita", 
        "id": "sg:person.01121053544.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121053544.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione", 
          "id": "https://www.grid.ac/institutes/grid.419539.3", 
          "name": [
            "INRAN, National Research Institute on Food and Nutrition, via Ardeatina 546, 00178, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perozzi", 
        "givenName": "Giuditta", 
        "id": "sg:person.01232401130.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232401130.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ceb.2005.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002541474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m408361200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004961505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m305000200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005284705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2003.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007242003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2003.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007242003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2003.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007242003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200462200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010117746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.25.14934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018090428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-003-1074-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019144559", 
          "https://doi.org/10.1007/s00424-003-1074-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m409962200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019440324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.9178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021872418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02829935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024099402", 
          "https://doi.org/10.1007/bf02829935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02829935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024099402", 
          "https://doi.org/10.1007/bf02829935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m007339200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024190418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00504340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024835879", 
          "https://doi.org/10.1007/bf00504340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00504340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024835879", 
          "https://doi.org/10.1007/bf00504340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.1146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025113196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026089133", 
          "https://doi.org/10.1038/sj.onc.1206797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026089133", 
          "https://doi.org/10.1038/sj.onc.1206797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1994.tb19043.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027285173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-003-0952-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028271235", 
          "https://doi.org/10.1007/s00439-003-0952-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-003-0952-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028271235", 
          "https://doi.org/10.1007/s00439-003-0952-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02024322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029906020", 
          "https://doi.org/10.1007/bf02024322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02024322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029906020", 
          "https://doi.org/10.1007/bf02024322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031850530", 
          "https://doi.org/10.1038/ng913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031850530", 
          "https://doi.org/10.1038/ng913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-003-3148-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033207614", 
          "https://doi.org/10.1007/s00018-003-3148-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0406216101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034407530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-003-1070-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034672574", 
          "https://doi.org/10.1007/s00424-003-1070-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1197-292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035224639", 
          "https://doi.org/10.1038/ng1197-292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200910200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041513935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.9.2330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045338695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-002-8454-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046374327", 
          "https://doi.org/10.1007/s00018-002-8454-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m207644200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051908328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3640105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053264850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3640105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053264850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/319514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058622740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/341125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058638908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.619449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062635050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00094.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063197084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138945006776818683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069180372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074544770", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1999.277.6.g1231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074563838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/130.5.1085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074636572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/130.5.1384s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074636620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/130.5.1399s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074636623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/130.5.1471s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074636634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/122.11.2233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076425914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/122.6.1214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077050385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jhered.a109990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081787413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00527.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082881245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00997.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083009701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00997.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083009701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/128.4.667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083234987"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-03", 
    "datePublishedReg": "2006-03-01", 
    "description": "The lethal milk mouse syndrome is caused by a point mutation in the zinc transporter gene ZnT4 resulting in defective zinc secretion in the milk of homozygous mutant dams. Pups of any genotype fed solely on lm milk die within the first two weeks of neonatal life, displaying zinc deficiency symptoms. Homozygous mutant pups survive when foster nursed by wild type dams and show signs of mild zinc deficiency in adulthood. To further investigate the role of ZnT4 in zinc secretion in the intestinal epithelium, we have studied the expression by real time quantitative PCR of mutant ZnT4 and of other zinc transporters of the Zip and ZnT families, in the jejunum of homozygous lm mice and of the isogenic wild type strain C57BL/ 6J. We report in this paper that expression of the mutant ZnT4 mRNA, carrying a premature translational termination codon (ZnT4/lm), is almost absent in tissues from lm mice, probably as a result of degradation by the Nonsense Mediated mRNA Decay (NMD) Pathway. In the jejunum of mutant mice, we also observed decreased expression of the uptake zinc transporter Zip4, paralleled by increased levels of both metallothionein genes MTI and MTII. Zinc supplementation of lm mice in the drinking water did not result in further decrease of Zip4 expression, but led to full induction of MT mRNAs. These results lead us to conclude that, although in the enterocytes of lm mice the absence of the zinc secretion activity mediated by ZnT4 results in increased intracellular zinc concentration, other zinc efflux activities are able to maintain the level of zinc ions below the threshold necessary for full induction of metallothioneins.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf02829937", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1037294", 
        "issn": [
          "1555-8932", 
          "1865-3499"
        ], 
        "name": "Genes & Nutrition", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "The Znt4 mutation inlethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters", 
    "pagination": "61-70", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "61f1356a3f6cf682970706ec909448fe98e5a5c8b50483f26670793de4cd6ed7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18850221"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101280108"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02829937"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020555297"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02829937", 
      "https://app.dimensions.ai/details/publication/pub.1020555297"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130817_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF02829937"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02829937'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02829937'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02829937'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02829937'


 

This table displays all metadata directly associated to this object as RDF triples.

232 TRIPLES      21 PREDICATES      73 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02829937 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N108db05fea914faf851a08d695c04842
4 schema:citation sg:pub.10.1007/bf00504340
5 sg:pub.10.1007/bf02024322
6 sg:pub.10.1007/bf02829935
7 sg:pub.10.1007/s00018-002-8454-2
8 sg:pub.10.1007/s00018-003-3148-y
9 sg:pub.10.1007/s00424-003-1070-7
10 sg:pub.10.1007/s00424-003-1074-3
11 sg:pub.10.1007/s00439-003-0952-2
12 sg:pub.10.1038/ng1197-292
13 sg:pub.10.1038/ng913
14 sg:pub.10.1038/sj.onc.1206797
15 https://app.dimensions.ai/details/publication/pub.1074544770
16 https://doi.org/10.1002/bies.1146
17 https://doi.org/10.1002/humu.9178
18 https://doi.org/10.1002/j.1460-2075.1996.tb00527.x
19 https://doi.org/10.1002/j.1460-2075.1996.tb00997.x
20 https://doi.org/10.1016/j.ceb.2005.04.005
21 https://doi.org/10.1016/j.yexcr.2003.07.001
22 https://doi.org/10.1042/bj3640105
23 https://doi.org/10.1073/pnas.0406216101
24 https://doi.org/10.1073/pnas.93.25.14934
25 https://doi.org/10.1074/jbc.m007339200
26 https://doi.org/10.1074/jbc.m200462200
27 https://doi.org/10.1074/jbc.m200910200
28 https://doi.org/10.1074/jbc.m207644200
29 https://doi.org/10.1074/jbc.m305000200
30 https://doi.org/10.1074/jbc.m408361200
31 https://doi.org/10.1074/jbc.m409962200
32 https://doi.org/10.1086/319514
33 https://doi.org/10.1086/341125
34 https://doi.org/10.1093/jn/122.11.2233
35 https://doi.org/10.1093/jn/122.6.1214
36 https://doi.org/10.1093/jn/128.4.667
37 https://doi.org/10.1093/jn/130.5.1085
38 https://doi.org/10.1093/jn/130.5.1384s
39 https://doi.org/10.1093/jn/130.5.1399s
40 https://doi.org/10.1093/jn/130.5.1471s
41 https://doi.org/10.1093/oxfordjournals.jhered.a109990
42 https://doi.org/10.1111/j.1432-1033.1994.tb19043.x
43 https://doi.org/10.1126/science.619449
44 https://doi.org/10.1152/ajpgi.1999.277.6.g1231
45 https://doi.org/10.1152/ajprenal.00094.2002
46 https://doi.org/10.2174/138945006776818683
47 https://doi.org/10.2337/diabetes.53.9.2330
48 schema:datePublished 2006-03
49 schema:datePublishedReg 2006-03-01
50 schema:description The lethal milk mouse syndrome is caused by a point mutation in the zinc transporter gene ZnT4 resulting in defective zinc secretion in the milk of homozygous mutant dams. Pups of any genotype fed solely on lm milk die within the first two weeks of neonatal life, displaying zinc deficiency symptoms. Homozygous mutant pups survive when foster nursed by wild type dams and show signs of mild zinc deficiency in adulthood. To further investigate the role of ZnT4 in zinc secretion in the intestinal epithelium, we have studied the expression by real time quantitative PCR of mutant ZnT4 and of other zinc transporters of the Zip and ZnT families, in the jejunum of homozygous lm mice and of the isogenic wild type strain C57BL/ 6J. We report in this paper that expression of the mutant ZnT4 mRNA, carrying a premature translational termination codon (ZnT4/lm), is almost absent in tissues from lm mice, probably as a result of degradation by the Nonsense Mediated mRNA Decay (NMD) Pathway. In the jejunum of mutant mice, we also observed decreased expression of the uptake zinc transporter Zip4, paralleled by increased levels of both metallothionein genes MTI and MTII. Zinc supplementation of lm mice in the drinking water did not result in further decrease of Zip4 expression, but led to full induction of MT mRNAs. These results lead us to conclude that, although in the enterocytes of lm mice the absence of the zinc secretion activity mediated by ZnT4 results in increased intracellular zinc concentration, other zinc efflux activities are able to maintain the level of zinc ions below the threshold necessary for full induction of metallothioneins.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N47624968e42b4f808465fd5d99d214c4
55 Nad141ba0b3424b68942ab5ce64f20064
56 sg:journal.1037294
57 schema:name The Znt4 mutation inlethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters
58 schema:pagination 61-70
59 schema:productId N5ee9272751844a0db68c0093fb0dab1f
60 N73100f8c71ef4e5eac1d22b0122c826b
61 Nc01df9af0b2547c4a634e9efd8c44e66
62 Nc7053c585caa412f850b0fc73e19f8b2
63 Nef7d70df86dd4048b550827bef8a0420
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020555297
65 https://doi.org/10.1007/bf02829937
66 schema:sdDatePublished 2019-04-11T13:56
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N5cd634e976c648f7bf673ab9f4ee2b99
69 schema:url http://link.springer.com/10.1007/BF02829937
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N108db05fea914faf851a08d695c04842 rdf:first sg:person.01134361174.60
74 rdf:rest N34435d717db848bd838d6cfead6fdcee
75 N2b5b663536674fa78b73383f9ddfe2e9 rdf:first sg:person.01121053544.02
76 rdf:rest Ndf52c3862c64483cabdadd211074a9e3
77 N34435d717db848bd838d6cfead6fdcee rdf:first sg:person.01212356130.28
78 rdf:rest N2b5b663536674fa78b73383f9ddfe2e9
79 N47624968e42b4f808465fd5d99d214c4 schema:volumeNumber 1
80 rdf:type schema:PublicationVolume
81 N5cd634e976c648f7bf673ab9f4ee2b99 schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N5ee9272751844a0db68c0093fb0dab1f schema:name doi
84 schema:value 10.1007/bf02829937
85 rdf:type schema:PropertyValue
86 N73100f8c71ef4e5eac1d22b0122c826b schema:name dimensions_id
87 schema:value pub.1020555297
88 rdf:type schema:PropertyValue
89 Nad141ba0b3424b68942ab5ce64f20064 schema:issueNumber 1
90 rdf:type schema:PublicationIssue
91 Nc01df9af0b2547c4a634e9efd8c44e66 schema:name readcube_id
92 schema:value 61f1356a3f6cf682970706ec909448fe98e5a5c8b50483f26670793de4cd6ed7
93 rdf:type schema:PropertyValue
94 Nc7053c585caa412f850b0fc73e19f8b2 schema:name pubmed_id
95 schema:value 18850221
96 rdf:type schema:PropertyValue
97 Ndf52c3862c64483cabdadd211074a9e3 rdf:first sg:person.01232401130.24
98 rdf:rest rdf:nil
99 Nef7d70df86dd4048b550827bef8a0420 schema:name nlm_unique_id
100 schema:value 101280108
101 rdf:type schema:PropertyValue
102 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
103 schema:name Biological Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
106 schema:name Genetics
107 rdf:type schema:DefinedTerm
108 sg:journal.1037294 schema:issn 1555-8932
109 1865-3499
110 schema:name Genes & Nutrition
111 rdf:type schema:Periodical
112 sg:person.01121053544.02 schema:affiliation https://www.grid.ac/institutes/grid.419539.3
113 schema:familyName Rami
114 schema:givenName Rita
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121053544.02
116 rdf:type schema:Person
117 sg:person.01134361174.60 schema:affiliation https://www.grid.ac/institutes/grid.419539.3
118 schema:familyName Murgia
119 schema:givenName Chiara
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134361174.60
121 rdf:type schema:Person
122 sg:person.01212356130.28 schema:affiliation https://www.grid.ac/institutes/grid.419539.3
123 schema:familyName Vespignani
124 schema:givenName Isabella
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212356130.28
126 rdf:type schema:Person
127 sg:person.01232401130.24 schema:affiliation https://www.grid.ac/institutes/grid.419539.3
128 schema:familyName Perozzi
129 schema:givenName Giuditta
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232401130.24
131 rdf:type schema:Person
132 sg:pub.10.1007/bf00504340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024835879
133 https://doi.org/10.1007/bf00504340
134 rdf:type schema:CreativeWork
135 sg:pub.10.1007/bf02024322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029906020
136 https://doi.org/10.1007/bf02024322
137 rdf:type schema:CreativeWork
138 sg:pub.10.1007/bf02829935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024099402
139 https://doi.org/10.1007/bf02829935
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/s00018-002-8454-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046374327
142 https://doi.org/10.1007/s00018-002-8454-2
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/s00018-003-3148-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033207614
145 https://doi.org/10.1007/s00018-003-3148-y
146 rdf:type schema:CreativeWork
147 sg:pub.10.1007/s00424-003-1070-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034672574
148 https://doi.org/10.1007/s00424-003-1070-7
149 rdf:type schema:CreativeWork
150 sg:pub.10.1007/s00424-003-1074-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019144559
151 https://doi.org/10.1007/s00424-003-1074-3
152 rdf:type schema:CreativeWork
153 sg:pub.10.1007/s00439-003-0952-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028271235
154 https://doi.org/10.1007/s00439-003-0952-2
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/ng1197-292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035224639
157 https://doi.org/10.1038/ng1197-292
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/ng913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031850530
160 https://doi.org/10.1038/ng913
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/sj.onc.1206797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026089133
163 https://doi.org/10.1038/sj.onc.1206797
164 rdf:type schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1074544770 schema:CreativeWork
166 https://doi.org/10.1002/bies.1146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025113196
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1002/humu.9178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021872418
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/j.1460-2075.1996.tb00527.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082881245
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/j.1460-2075.1996.tb00997.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1083009701
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.ceb.2005.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002541474
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.yexcr.2003.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007242003
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1042/bj3640105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053264850
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1073/pnas.0406216101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034407530
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1073/pnas.93.25.14934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018090428
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1074/jbc.m007339200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024190418
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1074/jbc.m200462200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010117746
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1074/jbc.m200910200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041513935
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1074/jbc.m207644200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051908328
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1074/jbc.m305000200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005284705
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1074/jbc.m408361200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004961505
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1074/jbc.m409962200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019440324
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1086/319514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058622740
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1086/341125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058638908
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1093/jn/122.11.2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076425914
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1093/jn/122.6.1214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077050385
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1093/jn/128.4.667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083234987
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1093/jn/130.5.1085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074636572
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/jn/130.5.1384s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074636620
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/jn/130.5.1399s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074636623
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1093/jn/130.5.1471s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074636634
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/oxfordjournals.jhered.a109990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081787413
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/j.1432-1033.1994.tb19043.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027285173
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1126/science.619449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062635050
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1152/ajpgi.1999.277.6.g1231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074563838
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1152/ajprenal.00094.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063197084
225 rdf:type schema:CreativeWork
226 https://doi.org/10.2174/138945006776818683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069180372
227 rdf:type schema:CreativeWork
228 https://doi.org/10.2337/diabetes.53.9.2330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045338695
229 rdf:type schema:CreativeWork
230 https://www.grid.ac/institutes/grid.419539.3 schema:alternateName Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione
231 schema:name INRAN, National Research Institute on Food and Nutrition, via Ardeatina 546, 00178, Roma, Italy
232 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...