A case of pleomorphic carcinoma of the pancreas showing sequential histological change by immunohistochemical study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-08

AUTHORS

Terumi Kamisawa, Ikuo Tabata, Tomoaki Isawa, Kouji Tsuruta, Atsutake Okamoto, Morio Koike

ABSTRACT

Pleomorphic carcinoma of the pancreas is a rare, histologically characterized pancreatic tumor with a rapid and fatal course. We report a case of a resected pleomorphic carcinoma located in the body of the pancreas in a 61-yr-old male. Histological analysis of the resected specimen revealed the coexistence of pleomorphic carcinoma with adenocarcinoma, but the recurrent tumors at autopsy 20 mo later were only of the adenocarcinomatous type. Cells in the adenocarcinomatous component showed a diffuse reactivity for CA19-9, CEA, and cytokeratin, and a focal reactivity for vimentin. In contrast, vimentin was diffusely expressed in pleomorphic lesion. Adenocarcinoma at autopsy expressed CA19-9, CEA, and cytokeratin, but not vimentin. These findings suggest that the recurrent adenocarcinoma may have developed as a consequence of sequential change in the nature of the tumor. More... »

PAGES

67-70

References to SciGraph publications

  • 1994. Anaplastic (Undifferentiated) Carcinoma in ATLAS OF EXOCRINE PANCREATIC TUMORS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02825423

    DOI

    http://dx.doi.org/10.1007/bf02825423

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1082427435

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7594772


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