The effect of soluble glucan derivates on spleen colony-forming units in sublethally irradiated mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08-01

AUTHORS

A. Líšková, J. Wagnerová, L. Červeňáková, A. Krištofová, M. Ferenčík

ABSTRACT

We examined the effects of 5 soluble derivatives of yeast glucan on the formation of exogenous (CFU-S) and endogenous (E-CFU) colony-forming units in the spleens of sublethally irradiated (60Co, 6.5–7.0 Gy) mice of two inbred strains. For the estimation of CFU-S, glucans were administered intravenously either to donors or recipients of spleen cells 24 h prior to irradiation or removal of the spleen. The number of CFU-S was increased when both the donors and recipients were treated with glucan; the highest increase was obtained with glucans S, P and K. All glucan preparations increased significantly also the number of E-CFU even when administered 90 min after irradiation. There exist differences in the response to the stimulatory effect of glucans among individual mouse strains. Thus, for example, the stimulatory effect of glucan KM on the E-CFU number was significantly more pronounced in strain A/Ph than in strain C57B1/6. More... »

PAGES

353-362

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02821287

DOI

http://dx.doi.org/10.1007/bf02821287

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042346188

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2262172


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