Inhibition of germ tube formation, filamentation and ergosterol biosynthesis inCandida albicans treated with 6-amino-2-n-pentylthiobenzothiazole View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-10

AUTHORS

S. Fábry, S. Gáborová, H. Bujdáková, M. Klobušický, A. Volleková, T. Kuchta

ABSTRACT

Three representative Candida albicans strains were selected out of 26 clinical isolates and strains from culture collections on the basis of their high level of conversion to germ tubes and mycelial form at mycelium-promoting culture conditions, and on their different sensitivity to 6-amino-2-n-pentylthiobenzothiazole (APB). When these strains were treated with APB at mycelium-promoting culture conditions, a concentration-dependent decrease in the proportion of germ tubes and hyphae was observed, while the proportion of the yeast from increased. When non-saponifiable lipids were extracted from these cultures and analyzed, a concentration-dependent decrease in ergosterol and an increase in 4-methylated sterols was observed. However, the sensitivity of sterol biosynthesis did not directly relate to the sensitivity of the morphological conversion, and was exhibited at higher concentrations of APB. On the basis of these results it is suggested that the inhibition of germ tube formation and filamentation is not a consequence of inhibition of ergosterol biosynthesis in APB-treated C. albicans. More... »

PAGES

523-526

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02816254

DOI

http://dx.doi.org/10.1007/bf02816254

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041015923

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10997135


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154 schema:name Department of Microbiology and Chemistry, Food Research Institute, 824 75, Bratislava, Slovakia
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156 https://www.grid.ac/institutes/grid.7634.6 schema:alternateName Comenius University
157 schema:name Department of Microbiology and Virology, Faculty of Science, Comenius University, 842 15, Bratislava
158 Department of Parasitology, Faculty of Medicine, Comenius University, Bratislava
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