Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-10

AUTHORS

Xinkang Wang, Tian-Li Yue, Frank C. Barone, Raymond F. White, Robert C. Gagnon, Giora Z. Feuerstein

ABSTRACT

The expression of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) mRNAs was significantly increased in the rat ischemic cortex following temporary occlusion of the middle cerebral artery (TMCAO) with reperfusion. Northern blot analysis demonstrated that the induction of TNF-alpha and IL-1 beta mRNAs occurred as early as 1 h after reperfusion, exhibiting a 4.6-fold increase (p < 0.05, n = 4) and 6.8-fold increase (p < 0.05, n = 4) in the ischemic cortex over control, respectively. TNF-alpha mRNA reached its peak at 3 h (8.0-fold, p < 0.05), whereas IL-1 beta mRNA reached its peak at 6 h (29.5-fold, p < 0.05). Both cytokine mRNA levels remained elevated for up to 2 d after reperfusion. In contrast to the time course of these cytokine mRNAs, c-fos and zif268 mRNAs, two early response genes, displayed a greater and earlier time-response profile. The early induction of c-fos and zif268 mRNAs in temporary brain ischemia with reperfusion suggests their roles in transcriptional regulation. The later concomitant expression of TNF-alpha and IL-1 beta suggests that these cytokines play an important role in the inflammatory response associated with focal ischemia. More... »

PAGES

103-114

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02815404

DOI

http://dx.doi.org/10.1007/bf02815404

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7702701


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