Localization of GTPase-activating protein-(GAP) like immunoreactivity in mouse cerebral regions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-08

AUTHORS

Misako Namima, Kyoko Takeuchi, Yasuhiro Watanabe, Mariko Yamano, Makoto Saito, Hidenori Sasa, Koichi Okamoto

ABSTRACT

GTPase-activating protein is known to regulate the conversion between ras-GTP and ras-GDP. We studied the basal expression of GTPase-activating protein-like immunoreactivity in mouse cerebral regions using a polyclonal anti-GTPase-activating protein antibody. Cells with GTPase-activating protein-like immunoreactivity were distributed in frontal cortical layers IV and V, and in the parietal cortex, piriform cortex, amygdaloid area, septum, lateral thalamus, and hypothalamus. The GTPase-activating protein-like immunoreactivity was also observed in fiber-like structures in the caudate putamen, stria terminalis, internal capsule, and medial forebrain bundle, and around CA2 pyramidal cells in Ammon's horn. These results imply that GTPase-activating protein is constitutively expressed in mouse brain regions and may have physiological functions in specific neuronal pathways in the brain. More... »

PAGES

157-172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02815122

DOI

http://dx.doi.org/10.1007/bf02815122

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006695053

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10343977


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