The immunoadjuvant effect of soluble glucan derivatives in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-04

AUTHORS

J. Wagnerová, A. Líšková, L. Červeňáková, T. Trnovec, M. Ferenčík

ABSTRACT

We examined the effect of soluble derivatives of yeast glucan on the humoral immune response of various strains of inbred mice after administration of different doses according to various schedules. Glucan was injected i.v. or s.c. in a single dose or repeatedly. The immune response was examined by determining the titres of serum hemagglutinins against sheep erythrocytes (SRBC-Ab). The immunoadjuvant effect of glucan derivatives depends on the inbred strain used, on the dose of glucan, mode and time of administration with respect to antigen injection. The results have shown that the stimulatory effect of glucan derivatives occurred already after a single injection, the optimum dose being 10–20 mg/kg. Intravenous injection was more efficient than the subcutaneous one. In some cases, a slight increase of the spleen mass was observed. More... »

PAGES

198-204

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02814503

DOI

http://dx.doi.org/10.1007/bf02814503

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024861679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1823656


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