The excretion of dimethadione in pure pancreatic juice and bile in postoperative patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-04

AUTHORS

Aiji Noda, Tetsuo Hayakawa, Ribun Mizuno, Hirotsugu Hamano, Toshiyuki Murase, Tokimune Shibata

ABSTRACT

The excretion of dimethadione (DMO) in pure pancreatic juice and bile was studied in postoperative pa tients undergoing external drainage of pancreatic juice and in those who had undergone percutaneous trans hepatic cholangiodrainage. During and after oral administration of trimethadione, which is the precursor of DMO, pancreatic DMO concentration closely paralleled plasma DMO concentration. Pancreatic juice/plasma concentration ratio for DMO exceeded 1.0. In a patient with a large pancreatic cyst communi cating with the main pancreatic duct, pancreatic DMO concentration after single rapid injection of secretin inversely correlated with the flow rate, while its output depended directly on the rate. Biliary DMO output after secretin injection was closely dependent on the flow rate, but was extremely low. The present results are essentially compatible with the findings previously observed in dogs. More... »

PAGES

121-126

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02806934

DOI

http://dx.doi.org/10.1007/bf02806934

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039744152

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6735069


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