Serum pancreatic stone protein in pancreatic diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-04

AUTHORS

Tetsuo Hayakawa, Takaharu Kondo, Tokimune Shibata, Motoji Kitagawa, Yuzo Sakai, Hiroshi Sobajima, Makoto Tanikawa, Yasuyuki Nakae, Shinobu Hayakawa, Tomoyuki Katsuzaki, Noriyuki Tatemichi

ABSTRACT

Serum pancreatic stone protein (PSP) was determined in sera of pancreatic and nonpancreatic diseases using enzyme immunoassay specific to human PSP to study the diagnostic and pathophysiological significance of PSP. Serum PSP in acute pancreatitis (mean±SD=1075.4±2849.1 ng/mL,n=33) was significantly higher than that in controls (78.6±31.8 ng/mL,n=37,p<0.01), chronic pancreatitis (156.8±82.8 ng/mL,n=32,p<0.05), and pancreatic cancer (148.468.8 ng/mL,n=26,p<0.05). No significant difference was found between noncalcified and calcified chronic pancreatitis. Serum PSP levels were significantly higher in chronic renal failure under hemodialysis (1796.0±1492.9 ng/mL) than in other diseases such as peptic ulcer, liver cirrhosis, gallstone, and diabetes mellitus. Low but significant correlation was obtained between serum PSP and serum immunoreactive trypsin (r=0.22,p<0.05). Increased serum PSP levels in acute pancreatitis and chronic renal failure suggest that serum PSP levels reflect reflux from pancreatic secretion, release from damaged pancreatic acinar cells, or retention in circulation, and can be useful for diagnosis of acute pancreatitis, but not chronic calcified pancreatitis. More... »

PAGES

97-103

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02786077

DOI

http://dx.doi.org/10.1007/bf02786077

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1082833620

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8501356


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