Stem cell transplantation for metastatic breast cancer: analysis of tumor contamination View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

Edward A Stadtmauer, Donald E Tsai, Cheryl J Sickles, Rosemarie Mick, Selina M Luger, David L Porter, Patricia A Mangan, Lynn M Schuchter, Stephen J Schuster, Elwyn Y Loh, Deborah A Magee, Robert A Sachs, Mark E Wall, Jonni Moore, Gordon P Buzby, Ellen Zaleta, Malek Kamoun, Leslie E Silberstein

ABSTRACT

The purpose of this study was to determine the efficacy, engraftment kinetics, effect of bone marrow tumor contamination, and safety of high-dose therapy and granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood progenitor cell (PBPC) support for patients with responding metastatic breast cancer. Forty two patients underwent G-CSF (10 μg/kg) stimulated PBPC harvest. PBPC and bone marrow aspirates were analyzed by histologic and immunocytochemical methods for tumor contamination. Thirty-seven patients received high-dose therapy consisting of cyclophosphamide 6 g/m2, thiotepa 500 mg/m2, and carboplatin 800 mg/m2 (CTCb) given as an infusion over 4 d followed by PBPC reinfusion and G-CSF (5 μg/kg) support. No transplant related deaths or grade 4 toxicity was recorded. CD34+ cells/kg infused was predictive of neutrophil and platelet recovery. With a median follow-up of 38 months, three year survival was 44% with relapse-free survival of 19%. Histological bone marrow involvement, found in 10 patients, was a negative prognostic factor and was associated with a median relapse-free survival of 3.5 months. Tumor contamination of PBPC by immunohistochemical staining was present in 22.5% of patients and found not to be correlated with decreased survival. G-CSF stimulated PBPC collection followed by a single course of high dose chemotherapy and stem cell infusion with G-CSF stimulated marrow recovery leads to rapid, reliable engraftment with low toxicity and promising outcome in women with responding metastatic breast cancer. More... »

PAGES

279-288

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02785874

DOI

http://dx.doi.org/10.1007/bf02785874

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017041257

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10618691


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21 schema:description The purpose of this study was to determine the efficacy, engraftment kinetics, effect of bone marrow tumor contamination, and safety of high-dose therapy and granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood progenitor cell (PBPC) support for patients with responding metastatic breast cancer. Forty two patients underwent G-CSF (10 μg/kg) stimulated PBPC harvest. PBPC and bone marrow aspirates were analyzed by histologic and immunocytochemical methods for tumor contamination. Thirty-seven patients received high-dose therapy consisting of cyclophosphamide 6 g/m2, thiotepa 500 mg/m2, and carboplatin 800 mg/m2 (CTCb) given as an infusion over 4 d followed by PBPC reinfusion and G-CSF (5 μg/kg) support. No transplant related deaths or grade 4 toxicity was recorded. CD34+ cells/kg infused was predictive of neutrophil and platelet recovery. With a median follow-up of 38 months, three year survival was 44% with relapse-free survival of 19%. Histological bone marrow involvement, found in 10 patients, was a negative prognostic factor and was associated with a median relapse-free survival of 3.5 months. Tumor contamination of PBPC by immunohistochemical staining was present in 22.5% of patients and found not to be correlated with decreased survival. G-CSF stimulated PBPC collection followed by a single course of high dose chemotherapy and stem cell infusion with G-CSF stimulated marrow recovery leads to rapid, reliable engraftment with low toxicity and promising outcome in women with responding metastatic breast cancer.
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29 G-CSF support
30 PBPC
31 PBPC collection
32 PBPC harvests
33 PBPC reinfusion
34 analysis
35 aspirates
36 bone marrow aspirate
37 bone marrow involvement
38 breast cancer
39 cancer
40 carboplatin
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42 cell support
43 cell transplantation
44 cells/
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48 course
49 cyclophosphamide
50 death
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52 effect
53 efficacy
54 engraftment
55 engraftment kinetics
56 factors
57 grade 4 toxicity
58 granulocyte-colony stimulating factor
59 harvest
60 high-dose chemotherapy
61 high-dose therapy
62 histologic
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65 infusion
66 involvement
67 kinetics
68 low toxicity
69 m2
70 marrow aspirates
71 marrow involvement
72 marrow recovery
73 median relapse-free survival
74 metastatic breast cancer
75 method
76 months
77 negative prognostic factor
78 neutrophils
79 outcomes
80 patients
81 peripheral blood progenitor cell support
82 platelet recovery
83 progenitor cell support
84 prognostic factors
85 promising outcomes
86 purpose
87 recovery
88 reinfusion
89 relapse-free survival
90 reliable engraftment
91 safety
92 single course
93 staining
94 stem cell infusion
95 stimulating factor
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