Zinc protects against ultraviolet A1-induced DNA damage and apoptosis in cultured human fibroblasts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-09

AUTHORS

Marie-Th’erèse Leccia, Marie-Jeanne Richard, Alain Favier, Jean-Claude B’Eani

ABSTRACT

Ultraviolet Al (UVA1) radiation generates reactive oxygen species and the oxidative stress is known as a mediator of DNA damage and of apoptosis. We exposed cultured human cutaneous fibroblasts to UVA1 radiation (wavelengths in the 340–450-nm range with emission peak at 365 nm) and, using the alkaline unwinding method, we showed an immediate significant increase of DNA strand breaks in exposed cells. Apoptosis was determined by detecting cytoplasmic nucleosomes (enzyme-linked immunosorbent assay method) at different time points in fibroblasts exposed to different irradiation doses. In our conditions, UVA1 radiation induced an early (8 h) and a delayed (18 h) apoptosis. Delayed apoptosis increased in a UVA dosedependent manner. Zinc is an important metal for DNA protection and has been shown to have inhibitory effects on apoptosis. The addition of zinc (6.5 mg/L) as zinc chloride to the culture medium significantly decreased immediate DNA strand breaks in human skin fibroblasts. Moreover, zinc chloride significantly decreased UVA1-induced early and delayed apoptosis. Thus, these data show for the first time in normal cutaneous cultured cells that UVA1 radiation induces apoptosis. This apoptosis is biphasic and appears higher 18 h after the stress. Zinc supplementation can prevent both immediate DNA strand breakage and early and delayed apoptosis, suggesting that this metal could be of interest for skin cell protection against UVA1 irradiation. More... »

PAGES

177-190

References to SciGraph publications

  • 1993. Mechanisms of Oxidative Cell Damage in FREE RADICALS: FROM BASIC SCIENCE TO MEDICINE
  • 1993-05. Effect of zinc supplementation on resistance of cultured human skin fibroblasts toward oxidant stress in BIOLOGICAL TRACE ELEMENT RESEARCH
  • 1997-12. Involvement of zinc in intracellular oxidant/antioxidant balance in BIOLOGICAL TRACE ELEMENT RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02783870

    DOI

    http://dx.doi.org/10.1007/bf02783870

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002560856

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10468155


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