Effects of water-immersion-induced stress and intraperitoneal administration of brain-gut peptides upon immunoreactive thyrotropin-releasing hormone and prostaglandin E2 concentrations in the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-08

AUTHORS

Yoshiaki Maeda, Kimitomo Morise, Kazuo Kusugami, Kiyoshi Uchida, Atsushi Furusawa, Hiroshi Kaneko, Koichi Nakada, Terunori Mitsuma, Fumihiko Kurimoto

ABSTRACT

The effects of water-immersion-induced stress and intraperitoneal (i.p.) administration of selected neuropeptides on the levels of thyrotropin-releasing hormone (TRH) and prostaglandin E2 (PGE2) were studied in the rat stomach. Water-immersion caused a significant decrease immunoreactive-TRH (ir-TRH) concentrations in the stomach, and a significant increase in ir-TRH concentrations in the gastric juice. The concentrations of PGE2 were significantly increased at 0.5-4 hrs, and significantly decreased at 6-8 hrs after water-immersion. In the experiment of i.p. administration of selected neuropeptides, the level of ir-TRH in the stomach was significantly decreased after VIP injection, whereas it was significantly increased after beta-endorphin injection. The concentration of PGE2 was significantly decreased in the stomach after i.p. administration of TRH and VIP. However, it did not change after beta-endorphin injection. These results indicate that some neuropeptides may participate in regulating the endogenous level of PGE2 and that these interrelations between neuropeptides and PGE2 may be important as ulcerogenic factors in stress ulcers induced by water-immersion in the rat. More... »

PAGES

417-423

References to SciGraph publications

  • 1990-08. The effects of histamine on the concentrations of immunoreactive thyrotropin-releasing hormone in the stomach and hypothalamus in rats in JOURNAL OF GASTROENTEROLOGY
  • 1986-02. Physiology and pharmacology of prostaglandins in DIGESTIVE DISEASES AND SCIENCES
  • 1984-05. Prostaglandin release and nociceptor stimulation by peptides in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1985-11. The pathophysiology of peptic ulcer disease in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02782808

    DOI

    http://dx.doi.org/10.1007/bf02782808

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1077838382

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1916149


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