Immunohistochemical study on tissue inhibitors of metalloproteinases in normal and pathological human livers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-02

AUTHORS

Yoshihide Fukuda, Masami Imoto, Yasuo Koyama, Yuuji Miyazawa, Isao Nakano, Masami Hattori, Fumihiro Urano, Shuji Kodama, Kazushi Iwata, Taro Hayakawa

ABSTRACT

The localization of tissue inhibitor of metalloproteinases (TIMP) in normal and pathological livers was examined by immunohistochemistry using monoclonal antibodies at the light microscopic level. In normal liver, immunoreactive TIMP was detected in smooth muscle cells and endothelial cells of blood vessels, fibroblasts, bile duct cells and Kupffer cells, indicating that TIMP is likely to be a general element of the liver. Immunoreactivity was observed in newly-formed blood vessels, proliferating bile ductules, and fibroblasts in the expanded portal area and fibrous septa of chronic active hepatitis and cirrhosis. TIMP was strongly stained in the capsule of hepatocellular carcinoma. The intensity of the immunoreaction in the capsule was generally greater than that in cirrhotic liver apart from the tumor mass. In three of five cases with hepatocellular carcinoma, endothelial walls in contact with tumor cells were positive. More... »

PAGES

37-41

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02779506

DOI

http://dx.doi.org/10.1007/bf02779506

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1077650347

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1848826


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