Activity of antibodies to hepatitis C virus of patients with chronic non-A, non-B hepatitis decreases during interferon α therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-07

AUTHORS

Kentaro Yoshioka, Shinichi Kakumu, Hisao Hayashi, Tadashi Shinagawa, Takaji Wakita, Tetsuya Ishikawa, Yuji Itoh, Masahiro Takayanagi

ABSTRACT

The activity of antibodies to hepatitis C virus (anti-HCV) was investigated in 80 patients with chronic non-A, non-B liver diseases. Anti-HCV antibodies were positive in 82.5% (66/80), and the titers were 1 for 18 patients, 2 for 40 and 3 for 8, respectively. The frequency of anti-HCV was significantly lower in patients with chronic persistent hepatitis (8/13, 61.5%) than in those with chronic active hepatitis (42/49, 85.7%) (P less than 0.05). There was no significant difference in the distribution of anti-HCV titers among the different stages of hepatitis. There was no correlation between anti-HCV titer and histology activity index score in chronic hepatitis. Activity of anti-HCV decreased more frequently in the patients who responded to interferon alpha (IFN alpha) therapy (8/22, 36.4%) than in those who did not (0/9, 0%) (P less than 0.05). These results indicate that anti-HCV activity does not correlate with the activity or disease stage of chronic hepatitis, but that anti-HCV activity decrease more frequently during IFN alpha treatment in patients who responded to IFN alpha therapy. More... »

PAGES

251-253

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02779312

DOI

http://dx.doi.org/10.1007/bf02779312

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1077201093

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1653165


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