A comparative study of once-a-day morning and once-a-day bedtime administration of 40 mg famotidine in treating duodenal ulcers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

Mitsuo Okada, Masahide Arita, Mitsuo Iida, Tsuneyoshi Yao, Toshihiro Sakurai, Kiyomi Hoshiko, Kazuhiro Maeda, Yasuhiro Okada, Kiyoto Sakamoto

ABSTRACT

A randomized controlled study comparing once-a-day morning and once-a-day bedtime administration of 40 mg famotidine in treating duodenal ulcers was carried out in 99 Japanese patients. Endoscopic examinations were performed at the baseline and repeated at 3-week intervals until healing was confirmed. Eighty-two patients fulfilled the evaluation criteria (38 in the morning group and 44 in the bedtime group). In 13 of these patients the antisecretory effects of these regimens were also assessed by 24 h intragastric pH monitoring. The healing rates were 66% after 3 weeks and 95% after 6 weeks in the morning group, and 57% after 3 weeks and 80% after 6 weeks in the bedtime group. The differences were insignificant between the two groups, but there was a higher healing rate tendency after 6 weeks in the morning group (0.05 More... »

PAGES

179-186

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02777720

DOI

http://dx.doi.org/10.1007/bf02777720

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046121867

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1577222


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