HBs-Ag, HBc-Ag and virus-like particles in liver tissue View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-09

AUTHORS

Seiichi Furuta, Atsuo Nagata, Kendo Kiyosawa, Toshihiro Takahashi, Yoshihiro Akahane, Yuriko Koike, Takeshi Sahara, Yoshihiro Iijima, Kenichi Furukawa, Tomoyuki Watanabe, Masako Hara, Akihiko Omori, Masayuki Oda

ABSTRACT

Hepatitis B surface antigen (HBs-Ag) and hepatitis B core antigen (HBc-Ag) in hepatic tissue of 3 cases with various liver diseases were investigated by immunofluorescent method. Virus-like particles were demonstrated by electron microscopy in the nuclei of these 3 cases. The localization of HBs-Ag was restricted in cytoplasma or on the surface of hepatocyte, while HBc-Ag was almost in the hepatocytic nuclei. However, there was unexplainable discrepancy between the distribution of HBs-Ag and that of HBc-Ag, as more the former in number and less that latter, of hepatocytes. The size of virus-like particles in nuclei was 22-27 nm in diameter. Most of them were hollow, but some of them were wholly electron dense. Their distribution was various from case to case. Discussion was made on the correlation between the presence of Hepatitis B virus and HBs-Ag or HBc-Ag. More... »

PAGES

208-214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02776654

DOI

http://dx.doi.org/10.1007/bf02776654

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1075161332

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1234098


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37 schema:description Hepatitis B surface antigen (HBs-Ag) and hepatitis B core antigen (HBc-Ag) in hepatic tissue of 3 cases with various liver diseases were investigated by immunofluorescent method. Virus-like particles were demonstrated by electron microscopy in the nuclei of these 3 cases. The localization of HBs-Ag was restricted in cytoplasma or on the surface of hepatocyte, while HBc-Ag was almost in the hepatocytic nuclei. However, there was unexplainable discrepancy between the distribution of HBs-Ag and that of HBc-Ag, as more the former in number and less that latter, of hepatocytes. The size of virus-like particles in nuclei was 22-27 nm in diameter. Most of them were hollow, but some of them were wholly electron dense. Their distribution was various from case to case. Discussion was made on the correlation between the presence of Hepatitis B virus and HBs-Ag or HBc-Ag.
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