The role of thyrotropin-releasing hormone (TRH) in the pathogenesis of water-immersion stress in rats—inhibition of TRH release from the stomach ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-02

AUTHORS

Kiyoshi Uchida, Terunori Mitsuma, Kimitomo Morise, Hiroshi Kaneko, Hirofumi Nagai, Atsushi Furusawa, Kouichi Nakada, Yoshiaki Maeda

ABSTRACT

The role of thyrotropin-releasing hormone (TRH) in the development of gastric erosions and ulcers induced by water-immersion stress was studied. Intraperitoneally administered bethanechol induced a decrease in the gastric wall immunoreactive TRH (ir-TRH) concentrations and an increase in gastric juice ir-TRH concentrations in a dose-related manner, while atropine induced an increase in gastric wall ir-TRH concentrations and a decrease in gastric juice ir-TRH concentrations under non-stress condition. Intraperitoneally administered omeprazole did not influence gastric wall ir-TRH concentrations but elevated gastric pH. Water-immersion stress induced a decrease in gastric wall ir-TRH concentrations and an increase in gastric juice ir-TRH concentrations with a decrease in gastric pH prior to ulcer formation. Pretreatment with atropine or ranitidine inhibited the development of stress ulcers, reduced changes in ir-TRH concentrations in the gastric wall and gastric juice, and induced an increase in gastric pH. Omeprazole inhibited stress ulcer formation and changes in gastric wall and gastric juice ir-TRH concentrations. These results suggest that TRH release from the stomach wall into gastric juice is of importance in the pathogenesis of stress ulcer and that its release is mediated by both muscarinergic and histaminergic (H2) systems. Furthermore, omeprazole has an inhibitory effect on TRH release under stress ulcer. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02774997

DOI

http://dx.doi.org/10.1007/bf02774997

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8095031


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