Immunological studies on crohn’s disease V. Enumeration of circulating lymphocytes subsets using monoclonal antibodies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-10

AUTHORS

Nobuo Okabe, Koichi Fujita, Misao Yamasaki, Tsuneyoshi Yao, Sumiaki Tsuru

ABSTRACT

We found normal levels of suppressor cell activity and reduced natural killer (NK) and antibody dependent cellmediated cytotoxicity (ADCC) activities in patients with Crohn’s disease (CD). To further characterize these activities, studies were carried out using monoclonal antibodies. There were no changes in the proportion of OKT4 + (helper/inducer T cells), OKT8 + or Leu 2 + (suppressor/cytotoxic T cells) and Leu 7 + cells (large granular lymphocytes: LGL, NK + K cells), thereby suggesting that suppressor cell activity in CD is likely to be normal both in function and in number, and that depressed NK and ADCC activities are not due to a reduction in the number of NK or K cells but rather to functional defects. Using a double staining method, we noted a low percentage of both Leu 2 and Leu 7 positive cells in CD. More... »

PAGES

431-435

References to SciGraph publications

  • 1981-09. Spontaneous suppressor cell function in inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • 1982-11. T-Lymphocyte subpopulations in Crohn's disease: Definition by monoclonal antibodies in JOURNAL OF MOLECULAR MEDICINE
  • 1979-09. Gut mucosal lymphocytes in inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • 1980-08. Immune status in crohn's disease in JOURNAL OF MOLECULAR MEDICINE
  • 1981. Con A Induced Suppressor Cell Activity in IBD and Other Inflammatory Diseases in RECENT ADVANCES IN CROHN’S DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02774779

    DOI

    http://dx.doi.org/10.1007/bf02774779

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048116230

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2934288


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