Benzodiazepines in the brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-12

AUTHORS

J. H. Medina, C. Peña, M. Piva, C. Wolfman, M. L. de Stein, C. Wasowski, C. Da Cunha, I. Izquierdo, A. C. Paladini

ABSTRACT

Great progress has been made in the last 5 yr in demonstrating the presence of benzodiazepines (BDZs) in mammalian tissues, in beginning studies on the origin of these natural compounds, and in elucidating their possible biological roles. Many unanswered questions remain regarding the sources and biosynthetic pathways responsible for the presence of BDZs in brain and their different physiological and/or biochemical actions. This essay will focus on recent findings supporting that: (1) BDZs are of natural origin; (2) mammalian brain contains BDZs in concentrations ranging between 5.10−10–10−8M; (3) dietary source of BDZs might be a plausible explanation for their occurrence in animal tissues, including man; (4) the formation of BDZ-like molecules in brain is a possibility, experimentally supported; (5) BDZ-like molecules including diazepam andN-desmethyldiazepam are elevated in hepatic encephalopathy; and (6) natural BDZs in the brain are involved in the modulation of memory processes. Future studies using the full range of biochemical, physiological, behavioral, and molecular biological techniques available to the neuroscientist will hopefully continue to yield exciting and new information concerning the biological roles that BDZs might play in the normal and pathological functioning of the brain. More... »

PAGES

377-386

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02757942

DOI

http://dx.doi.org/10.1007/bf02757942

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031065784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1337455


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