Deficiency of phenylethanolamine N-methyltransferase in norepinephrine-producing pheochromocytoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

Noriko Kimura, Akira Togo, Takako Sugimoto, Koji Nata, Hiroshi Okamoto, Ikuko Nagatsu, Hiroshi Nagura

ABSTRACT

Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is not known whether the absence of immunoreactive PNMT is paralleled by a lack of PNMT mRNA. The mRNA of tyrosine hydroxylase (TH) and PNMT in seven pheochromocytomas, five NE-type and two E-type tumors, were examined by Northern blot analysis andin situ hybridization (ISH) technique. TH mRNA was detected in all tumors but PNMT mRNA was limited only to the E-type tumors. In addition to our previous immunohistochemical study of 70 pheochromocytomas and paragangliomas in which all pheochromocytomas had cells immunoreactive to TH, but PNMT was expressed only in E-type, we concluded that NE-type pheochromocytoma lacks PNMT both at the mRNA and protein levels, resulting in an inability to produce E. The essential difference between NE-type and E-type pheochromocytoma is that the NE-type lacks PNMT. More... »

PAGES

131-136

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02739972

DOI

http://dx.doi.org/10.1007/bf02739972

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015098376

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12114640


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Tohoku University School of Medicine, 2-1, Seiryo-machi Aoba-ku, 980-77, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Pathology, Tohoku University School of Medicine, 2-1, Seiryo-machi Aoba-ku, 980-77, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Noriko", 
        "id": "sg:person.01223337420.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223337420.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Tohoku University School of Medicine, Sendai", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Biochemistry, Tohoku University School of Medicine, Sendai"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Togo", 
        "givenName": "Akira", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Tohoku University School of Medicine, Sendai", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Biochemistry, Tohoku University School of Medicine, Sendai"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugimoto", 
        "givenName": "Takako", 
        "id": "sg:person.0646712130.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646712130.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Tohoku University School of Medicine, Sendai", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Biochemistry, Tohoku University School of Medicine, Sendai"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nata", 
        "givenName": "Koji", 
        "id": "sg:person.01131411741.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131411741.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Tohoku University School of Medicine, Sendai", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Biochemistry, Tohoku University School of Medicine, Sendai"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okamoto", 
        "givenName": "Hiroshi", 
        "id": "sg:person.010375015300.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010375015300.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomy, School of Medicine, Fujita Health University, Toyoake, Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Anatomy, School of Medicine, Fujita Health University, Toyoake, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagatsu", 
        "givenName": "Ikuko", 
        "id": "sg:person.01030764465.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030764465.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Tohoku University School of Medicine, 2-1, Seiryo-machi Aoba-ku, 980-77, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Pathology, Tohoku University School of Medicine, 2-1, Seiryo-machi Aoba-ku, 980-77, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagura", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0723362470.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01607135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025367268", 
          "https://doi.org/10.1007/bf01607135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02915625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007174977", 
          "https://doi.org/10.1007/bf02915625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328524a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014266847", 
          "https://doi.org/10.1038/328524a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-05", 
    "datePublishedReg": "1996-05-01", 
    "description": "Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is not known whether the absence of immunoreactive PNMT is paralleled by a lack of PNMT mRNA. The mRNA of tyrosine hydroxylase (TH) and PNMT in seven pheochromocytomas, five NE-type and two E-type tumors, were examined by Northern blot analysis andin situ hybridization (ISH) technique. TH mRNA was detected in all tumors but PNMT mRNA was limited only to the E-type tumors. In addition to our previous immunohistochemical study of 70 pheochromocytomas and paragangliomas in which all pheochromocytomas had cells immunoreactive to TH, but PNMT was expressed only in E-type, we concluded that NE-type pheochromocytoma lacks PNMT both at the mRNA and protein levels, resulting in an inability to produce E. The essential difference between NE-type and E-type pheochromocytoma is that the NE-type lacks PNMT.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf02739972", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1100468", 
        "issn": [
          "1046-3976", 
          "1559-0097"
        ], 
        "name": "Endocrine Pathology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "phenylethanolamine N-methyltransferase", 
      "tyrosine hydroxylase", 
      "plasma Ca levels", 
      "previous immunohistochemical studies", 
      "PNMT mRNA", 
      "N-methyltransferase", 
      "immunoreactive phenylethanolamine-N-methyltransferase", 
      "immunohistochemical study", 
      "pheochromocytoma", 
      "norepinephrine", 
      "TH mRNA", 
      "tumors", 
      "protein levels", 
      "CA synthesis", 
      "situ hybridization technique", 
      "Ca levels", 
      "mRNA", 
      "hybridization technique", 
      "paraganglioma", 
      "catecholamines", 
      "NE types", 
      "hydroxylase", 
      "levels", 
      "terminal enzyme", 
      "E-type", 
      "deficiency", 
      "cells", 
      "inability", 
      "absence", 
      "differences", 
      "study", 
      "types", 
      "lack", 
      "enzyme", 
      "addition", 
      "synthesis", 
      "technique", 
      "essential difference"
    ], 
    "name": "Deficiency of phenylethanolamine N-methyltransferase in norepinephrine-producing pheochromocytoma", 
    "pagination": "131-136", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015098376"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02739972"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12114640"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02739972", 
      "https://app.dimensions.ai/details/publication/pub.1015098376"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_274.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf02739972"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02739972'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02739972'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02739972'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02739972'


 

This table displays all metadata directly associated to this object as RDF triples.

157 TRIPLES      21 PREDICATES      67 URIs      56 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02739972 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nf69322b8fda64cffaa73ecf4d5c39b2c
4 schema:citation sg:pub.10.1007/bf01607135
5 sg:pub.10.1007/bf02915625
6 sg:pub.10.1038/328524a0
7 schema:datePublished 1996-05
8 schema:datePublishedReg 1996-05-01
9 schema:description Pheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is not known whether the absence of immunoreactive PNMT is paralleled by a lack of PNMT mRNA. The mRNA of tyrosine hydroxylase (TH) and PNMT in seven pheochromocytomas, five NE-type and two E-type tumors, were examined by Northern blot analysis andin situ hybridization (ISH) technique. TH mRNA was detected in all tumors but PNMT mRNA was limited only to the E-type tumors. In addition to our previous immunohistochemical study of 70 pheochromocytomas and paragangliomas in which all pheochromocytomas had cells immunoreactive to TH, but PNMT was expressed only in E-type, we concluded that NE-type pheochromocytoma lacks PNMT both at the mRNA and protein levels, resulting in an inability to produce E. The essential difference between NE-type and E-type pheochromocytoma is that the NE-type lacks PNMT.
10 schema:genre article
11 schema:isAccessibleForFree false
12 schema:isPartOf N695ed4b7617b4f219d208b1841cb769f
13 Nbcb2243a28be4bac91308cbba166bbae
14 sg:journal.1100468
15 schema:keywords CA synthesis
16 Ca levels
17 E-type
18 N-methyltransferase
19 NE types
20 PNMT mRNA
21 TH mRNA
22 absence
23 addition
24 catecholamines
25 cells
26 deficiency
27 differences
28 enzyme
29 essential difference
30 hybridization technique
31 hydroxylase
32 immunohistochemical study
33 immunoreactive phenylethanolamine-N-methyltransferase
34 inability
35 lack
36 levels
37 mRNA
38 norepinephrine
39 paraganglioma
40 phenylethanolamine N-methyltransferase
41 pheochromocytoma
42 plasma Ca levels
43 previous immunohistochemical studies
44 protein levels
45 situ hybridization technique
46 study
47 synthesis
48 technique
49 terminal enzyme
50 tumors
51 types
52 tyrosine hydroxylase
53 schema:name Deficiency of phenylethanolamine N-methyltransferase in norepinephrine-producing pheochromocytoma
54 schema:pagination 131-136
55 schema:productId N1adf17052fb04f27bf65f34cbee837f7
56 N958580cbe61e4f5da275a1f41f53ef73
57 Ndb84b2dea6c24660bcc582b094570f33
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015098376
59 https://doi.org/10.1007/bf02739972
60 schema:sdDatePublished 2022-08-04T16:53
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N3cbc52ebc98f4c8da5fa9bfa739d6daa
63 schema:url https://doi.org/10.1007/bf02739972
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0cdaf2d50b134cf6ba8eaae61f514419 rdf:first sg:person.0646712130.35
68 rdf:rest N9c6decdeaf944189825be51ca85589d0
69 N1adf17052fb04f27bf65f34cbee837f7 schema:name pubmed_id
70 schema:value 12114640
71 rdf:type schema:PropertyValue
72 N3cbc52ebc98f4c8da5fa9bfa739d6daa schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N518760bb841b46ce8a4decf869141a8c schema:affiliation grid-institutes:grid.69566.3a
75 schema:familyName Togo
76 schema:givenName Akira
77 rdf:type schema:Person
78 N5b16089a496147e1b050e95c5ccc7bf9 rdf:first sg:person.0723362470.15
79 rdf:rest rdf:nil
80 N695ed4b7617b4f219d208b1841cb769f schema:volumeNumber 7
81 rdf:type schema:PublicationVolume
82 N958580cbe61e4f5da275a1f41f53ef73 schema:name doi
83 schema:value 10.1007/bf02739972
84 rdf:type schema:PropertyValue
85 N979000a7fed84b18bdaad1eb6c610f92 rdf:first N518760bb841b46ce8a4decf869141a8c
86 rdf:rest N0cdaf2d50b134cf6ba8eaae61f514419
87 N9c6decdeaf944189825be51ca85589d0 rdf:first sg:person.01131411741.57
88 rdf:rest Nb2088cad18f34c4791138af94cf6ec88
89 Nb2088cad18f34c4791138af94cf6ec88 rdf:first sg:person.010375015300.30
90 rdf:rest Nb7c2c9f5d9a4489d8744f13bea4807a1
91 Nb7c2c9f5d9a4489d8744f13bea4807a1 rdf:first sg:person.01030764465.69
92 rdf:rest N5b16089a496147e1b050e95c5ccc7bf9
93 Nbcb2243a28be4bac91308cbba166bbae schema:issueNumber 2
94 rdf:type schema:PublicationIssue
95 Ndb84b2dea6c24660bcc582b094570f33 schema:name dimensions_id
96 schema:value pub.1015098376
97 rdf:type schema:PropertyValue
98 Nf69322b8fda64cffaa73ecf4d5c39b2c rdf:first sg:person.01223337420.14
99 rdf:rest N979000a7fed84b18bdaad1eb6c610f92
100 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
101 schema:name Medical and Health Sciences
102 rdf:type schema:DefinedTerm
103 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
104 schema:name Clinical Sciences
105 rdf:type schema:DefinedTerm
106 sg:journal.1100468 schema:issn 1046-3976
107 1559-0097
108 schema:name Endocrine Pathology
109 schema:publisher Springer Nature
110 rdf:type schema:Periodical
111 sg:person.01030764465.69 schema:affiliation grid-institutes:grid.256115.4
112 schema:familyName Nagatsu
113 schema:givenName Ikuko
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030764465.69
115 rdf:type schema:Person
116 sg:person.010375015300.30 schema:affiliation grid-institutes:grid.69566.3a
117 schema:familyName Okamoto
118 schema:givenName Hiroshi
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010375015300.30
120 rdf:type schema:Person
121 sg:person.01131411741.57 schema:affiliation grid-institutes:grid.69566.3a
122 schema:familyName Nata
123 schema:givenName Koji
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131411741.57
125 rdf:type schema:Person
126 sg:person.01223337420.14 schema:affiliation grid-institutes:grid.69566.3a
127 schema:familyName Kimura
128 schema:givenName Noriko
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223337420.14
130 rdf:type schema:Person
131 sg:person.0646712130.35 schema:affiliation grid-institutes:grid.69566.3a
132 schema:familyName Sugimoto
133 schema:givenName Takako
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646712130.35
135 rdf:type schema:Person
136 sg:person.0723362470.15 schema:affiliation grid-institutes:grid.69566.3a
137 schema:familyName Nagura
138 schema:givenName Hiroshi
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15
140 rdf:type schema:Person
141 sg:pub.10.1007/bf01607135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025367268
142 https://doi.org/10.1007/bf01607135
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/bf02915625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007174977
145 https://doi.org/10.1007/bf02915625
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/328524a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014266847
148 https://doi.org/10.1038/328524a0
149 rdf:type schema:CreativeWork
150 grid-institutes:grid.256115.4 schema:alternateName Department of Anatomy, School of Medicine, Fujita Health University, Toyoake, Japan
151 schema:name Department of Anatomy, School of Medicine, Fujita Health University, Toyoake, Japan
152 rdf:type schema:Organization
153 grid-institutes:grid.69566.3a schema:alternateName Department of Biochemistry, Tohoku University School of Medicine, Sendai
154 Department of Pathology, Tohoku University School of Medicine, 2-1, Seiryo-machi Aoba-ku, 980-77, Sendai, Japan
155 schema:name Department of Biochemistry, Tohoku University School of Medicine, Sendai
156 Department of Pathology, Tohoku University School of Medicine, 2-1, Seiryo-machi Aoba-ku, 980-77, Sendai, Japan
157 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...