Ontology type: schema:ScholarlyArticle
1996-05
AUTHORSNoriko Kimura, Akira Togo, Takako Sugimoto, Koji Nata, Hiroshi Okamoto, Ikuko Nagatsu, Hiroshi Nagura
ABSTRACTPheochromocytoma is a catecholamine (CA)-producing tumor that is classified into two types: the norepinephrine (NE) and the mixed NE and epinephrine type (E-type) from plasma CA levels. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in CA synthesis; it catalyzes the synthesis of E from NE. It is not known whether the absence of immunoreactive PNMT is paralleled by a lack of PNMT mRNA. The mRNA of tyrosine hydroxylase (TH) and PNMT in seven pheochromocytomas, five NE-type and two E-type tumors, were examined by Northern blot analysis andin situ hybridization (ISH) technique. TH mRNA was detected in all tumors but PNMT mRNA was limited only to the E-type tumors. In addition to our previous immunohistochemical study of 70 pheochromocytomas and paragangliomas in which all pheochromocytomas had cells immunoreactive to TH, but PNMT was expressed only in E-type, we concluded that NE-type pheochromocytoma lacks PNMT both at the mRNA and protein levels, resulting in an inability to produce E. The essential difference between NE-type and E-type pheochromocytoma is that the NE-type lacks PNMT. More... »
PAGES131-136
http://scigraph.springernature.com/pub.10.1007/bf02739972
DOIhttp://dx.doi.org/10.1007/bf02739972
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12114640
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