Tumor modifier genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

José Fernández-Piqueras, Javier Santos Hernández

ABSTRACT

Inheritance based on the allele combination of multiple tumor modifier genes capable of modulate the phenotype manifestation of mutant major-cancer-predisposition genes is essential to determine the risk of cancer, and the response to drug treatment in a given individual. A tumor modifier gene may be either a functional polymorphism of a major-predisposition gene (tumor suppressor gene or proto-oncogene), or any other type of genes whose products may interfere the tumor phenotype caused by alterations in the major-predisposition genes. Experimental mouse models provide an useful genetic tool for identifying these genes. More... »

PAGES

349-357

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    DOI

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