Ontology type: schema:ScholarlyArticle
2003-10
AUTHORSOrganizada por el Instituto Catalán de Oncología de Barcelona, F. Guedea, y el Instituto Valenciano de Oncología de Valencia, L. Arribas, bajo los auspicios de la Asociación Española de Radioterapia (AERO), F. Casquero, C. Cinos, V. Crispin, A. Gracia, J. L. Guinot, I. Monteiro-Grillo, V. Munoz, J. Pera, A. Polo, L. Linares, H. Marsiglia, J. J. Mazeron
ABSTRACTExiste una controversia desde hace décadas sobre el papel de la sobredosis después de la radioterapia externa en el tratamiento conservador de cáncer de mama inicial. En el caso de comparar la supervivencia y el control local de un tratamiento conservador frente a la mastectomía, existen en la literatura 5 estudios randomizados1–5 y un metaanálisis6 que demuestran que la radioterapia externa con una dosis de 50 Gy después de la cirugía conservadora disminuye la tasa de recidiva de un 35% a un 10%. Recientemente, ha sido publicado el primer estudio randomizado y coordinado por la EORTC sobre el papel de la sobredosis con 16 Gy después de la cirugía conservadora y la radioterapia externa con 50 Gy. La conclusión de este estudio es clara; la utilización de la sobredosis reduce el riesgo de recidiva local, especialmente en pacientes con edad menor de 50 años7. Otro estudio randomizado realizado en Lyon8 demuestra asimismo que unboost de 10 Gy disminuye la tasa de recidivas locales (4,5% de recidivas locales sinboost frente al 5,6% de recidivas locales conboost, p=0,044). Por tanto, estos estudios randomizados confirman la utilidad de la sobredosis. En cambio persisten las dudas sobre cómo hay que administrar esteboost y en particular cuándo hay que hacer la braquiterapia. La actualidad de este tema nos motivó para organizar esta reunión de consenso en España. More... »
PAGES413-418
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DOIhttp://dx.doi.org/10.1007/bf02711472
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