Functional and pathological significance of phospholipid asymmetry in erythrocyte membranes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-09

AUTHORS

Robert A. Schlegel, Susan Kemper, Patrick Williamson

ABSTRACT

The normal asymmetric distribution of phospholipids in the plasma membrane is perturbed in erythrocytes from patients with chronic myelogenous leukemia. Since experimentally-produced lipid-symmetric erythrocytes are more interactive with cells of the reticuloendothelial system than are their lipid-asymmetric counterparts, the biological recognition of chronic myelogenous leukemia erythrocytes by the reticuloendothelial system was examined. With one exception, all erythrocyte samples from patients with chronic/benign chronic myelogenous leukemia were more adherent to endothelial cells and more readily phagocytosed by macrophagesin vitro than were normal erythrocytes. Thus, these naturally occurring pathological erythrocytes display the same dysfunctional intercellular interactions as the laboratory models. More... »

PAGES

187-191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02703883

DOI

http://dx.doi.org/10.1007/bf02703883

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026571400


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