Interaction andin vivo growth inhibition of Ehrlich ascites tumor cells by jacalin View Full Text


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Article Info

DATE

1988-12-01

AUTHORS

H. Ahmed, B. P. Chatterjee, A. K. Debnath

ABSTRACT

Jacalin has been found to agglutinate Ehrlich ascites cells. The agglutination was inhibited by α-glycosides of D-Gal and β -D-Gal(1 → 3)-D-GalNAc suggesting that the lectin-ascites interaction was carbohydrate-specific. There was 21.8% inhibition of tumour (ascites) cell growthin vivo in mice administered 50μg of jacalin by injection for 6 days following intraperitoneal injection of ascites cells. Administration of 100, 150 and 200μg jacalin resulted in 40.2, 57.5 and 83% inhibition respectively. Thein vivo inhibition of tumour cells growth by jacalin was due to its preferential binding with D-Gal-α -(1 → 6) present as terminal residues in the glycoprotein on tumour cell surface. More... »

PAGES

419-424

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02703454

DOI

http://dx.doi.org/10.1007/bf02703454

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013649412


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