Sulfur derivatives of N,N-Disubstituted amides of long chain fatty acids and their antimicrobial activities View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-11

AUTHORS

R. R. Mod, F. C. Magne, G. Sumrell, A. F. Novak

ABSTRACT

Mercaptoacetic acid was added to the internal double bond of N,N-disubstituted oleamides and the terminal double bond of 11-undecenoylmorpholine. Unreacted starting materials were removed by distillation and as urea complexes. The internal carboxyl group of N,N-disubstituted-9(10)-(carboxymethylthio)stearamides and the terminal carboxyl group of 11-(carboxymethylthio)undecanamide were esterified. Screening for broad range antimicrobial activity againstCandida albicans, Staphylococcus aureus, Escherichia coli, andAspergillus species indicated that all compounds tested were active. However, 9(10)-(carbomethoxymethylthio)stearoylmorpholine and 9(10)-carbethoxymethylthio)stearoyl-4-methylpiperidine were the most effective and strongly inhibited the growth of all organisms tested. More... »

PAGES

455-456

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02637488

DOI

http://dx.doi.org/10.1007/bf02637488

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053550013

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1184908


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