Effects of fibrin on the angiogenesis in vitro of bovine endothelial cells in collagen gel View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-06

AUTHORS

Akira Takei, Yoshihiko Tashiro, Yutaka Nakashima, Katsuo Sueishi

ABSTRACT

The effect of fibrin on angiogenesis in vitro was investigated using an experimental model of tube formation by bovine capillary endothelial cells (BCEs) in type I collagen gel. One milligram per milliliter of fibrin added into type I collagen gel significantly increased the length of the tubular structures formed by BCEs in the gel by about 180% compared with type I collagen only. The facilitating effect of fibrin on tube formation by BCEs was inhibited by either anti-basic fibroblast growth factor (bFGF) IgG (25 micrograms/ml) or anti-urokinase type plasminogen activator (uPA) IgG (10 micrograms/ml) added to the gel and culture medium, but not by anti-tissue type plasminogen activator (uPA) IgG (10 micrograms/ml) added to the gel and culture medium, but not by anti-tissue type plasminogen activator (10 micrograms/ml) or non-immune IgG. The Arg-Gly-Asp (RGD) containing peptides (100 micrograms/ml) added to the culture medium also suppressed tube formation by BCEs in fibrin-containing type I collagen gel, but not in type I collagen gel. These results suggest that the increased release of bFGF and uPA by BCEs therefore plays a role in the angiogenic effect of fibrin in vitro, and the angiogenic effect of fibrin is mediated by the RGD sequence in fibrin, probably via the function of integrin receptor of the BCEs. More... »

PAGES

467-472

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02634260

DOI

http://dx.doi.org/10.1007/bf02634260

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003126529

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8589891


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cattle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblast Growth Factor 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urokinase-Type Plasminogen Activator", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyushu University", 
          "id": "https://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "First Department of Pathology, Faculty of Medicine, Kyushu University 60, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takei", 
        "givenName": "Akira", 
        "id": "sg:person.0730113326.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730113326.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyushu University", 
          "id": "https://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "First Department of Pathology, Faculty of Medicine, Kyushu University 60, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tashiro", 
        "givenName": "Yoshihiko", 
        "id": "sg:person.0746243660.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746243660.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyushu University", 
          "id": "https://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "First Department of Pathology, Faculty of Medicine, Kyushu University 60, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakashima", 
        "givenName": "Yutaka", 
        "id": "sg:person.07456121032.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456121032.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyushu University", 
          "id": "https://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "First Department of Pathology, Faculty of Medicine, Kyushu University 60, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sueishi", 
        "givenName": "Katsuo", 
        "id": "sg:person.01232044316.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232044316.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci114322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001130120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(05)81179-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003853862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.6.11.4060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004289684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.107.4.1589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005436877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041540325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008329490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02630933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009638448", 
          "https://doi.org/10.1007/bf02630933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.109.2.811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011614714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02624102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013459818", 
          "https://doi.org/10.1007/bf02624102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02624102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013459818", 
          "https://doi.org/10.1007/bf02624102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.107.3.1199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016369740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.18.6471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017283198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.19.7297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017860011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.108.2.671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018243257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.7.2091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018736508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325257a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020191001", 
          "https://doi.org/10.1038/325257a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041490322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020898408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.109.2.823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035825260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1993.1031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036708699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.76.10.5217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036710787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198401193100307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037798000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041390317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038800108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.17.6487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040685393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.109.2.877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040848050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.111.2.731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044047535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(87)80220-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044926293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.104.5.1403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046531044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041250102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046651564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/288551a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048791001", 
          "https://doi.org/10.1038/288551a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00454828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051160805", 
          "https://doi.org/10.1007/bf00454828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00454828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051160805", 
          "https://doi.org/10.1007/bf00454828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-76849-1_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052568616", 
          "https://doi.org/10.1007/978-3-642-76849-1_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci111661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053599406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.97.5.1648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053711699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2425435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062537171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2821619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062563620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075303632", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077293455", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077315966", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078059855", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078848552", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078907766", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078998519", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079472265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081959973", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-06", 
    "datePublishedReg": "1995-06-01", 
    "description": "The effect of fibrin on angiogenesis in vitro was investigated using an experimental model of tube formation by bovine capillary endothelial cells (BCEs) in type I collagen gel. One milligram per milliliter of fibrin added into type I collagen gel significantly increased the length of the tubular structures formed by BCEs in the gel by about 180% compared with type I collagen only. The facilitating effect of fibrin on tube formation by BCEs was inhibited by either anti-basic fibroblast growth factor (bFGF) IgG (25 micrograms/ml) or anti-urokinase type plasminogen activator (uPA) IgG (10 micrograms/ml) added to the gel and culture medium, but not by anti-tissue type plasminogen activator (uPA) IgG (10 micrograms/ml) added to the gel and culture medium, but not by anti-tissue type plasminogen activator (10 micrograms/ml) or non-immune IgG. The Arg-Gly-Asp (RGD) containing peptides (100 micrograms/ml) added to the culture medium also suppressed tube formation by BCEs in fibrin-containing type I collagen gel, but not in type I collagen gel. These results suggest that the increased release of bFGF and uPA by BCEs therefore plays a role in the angiogenic effect of fibrin in vitro, and the angiogenic effect of fibrin is mediated by the RGD sequence in fibrin, probably via the function of integrin receptor of the BCEs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf02634260", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1312212", 
        "issn": [
          "1071-2690", 
          "1543-706X"
        ], 
        "name": "In Vitro Cellular & Developmental Biology - Animal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Effects of fibrin on the angiogenesis in vitro of bovine endothelial cells in collagen gel", 
    "pagination": "467-472", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0ee49f45dd92ca2c94c18c1a7df65610dc72164e2bcca92a840202fefd705c34"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8589891"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9418515"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02634260"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003126529"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02634260", 
      "https://app.dimensions.ai/details/publication/pub.1003126529"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000530.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF02634260"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02634260'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02634260'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02634260'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02634260'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      86 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02634260 schema:about N3f5ac2ac3c9f456e8c1597788599aa98
2 N4505477657634887abb6387d356388fe
3 N600ad4fabf634848975b450f95fbb276
4 N6b206f5fc20642dbb9f8e98568cf634d
5 N7583b80e8d5644298186aa25a7277492
6 N88f7543ac1fb406ab53138d0a8fb7951
7 N9f3ef284c7834f4e8308afddc748206c
8 Nb81a94d4ad4f436fba9167a3df15f9da
9 Nc2dbbd6034574c369673b277e7f47837
10 Nc4220b197ed34f0980d5bf705b26d069
11 Ndd45cc69ae61462080fc45dd8a98ccea
12 Ne1f5e1a2eae84f50913b9fd8ccbd70f5
13 Nee85230399664a40830774c9d677ce12
14 Nfbd1b68db2c34c6282ba0bacc78cc759
15 Nfeab2c96566c4b14a6a3c03fca1b6e1a
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author Nd15d8c1b016f4aaca4b8e3abe5e52fbf
19 schema:citation sg:pub.10.1007/978-3-642-76849-1_2
20 sg:pub.10.1007/bf00454828
21 sg:pub.10.1007/bf02624102
22 sg:pub.10.1007/bf02630933
23 sg:pub.10.1038/288551a0
24 sg:pub.10.1038/325257a0
25 https://app.dimensions.ai/details/publication/pub.1075303632
26 https://app.dimensions.ai/details/publication/pub.1077293455
27 https://app.dimensions.ai/details/publication/pub.1077315966
28 https://app.dimensions.ai/details/publication/pub.1078059855
29 https://app.dimensions.ai/details/publication/pub.1078848552
30 https://app.dimensions.ai/details/publication/pub.1078907766
31 https://app.dimensions.ai/details/publication/pub.1078998519
32 https://app.dimensions.ai/details/publication/pub.1079472265
33 https://app.dimensions.ai/details/publication/pub.1081959973
34 https://doi.org/10.1002/jcp.1041250102
35 https://doi.org/10.1002/jcp.1041390317
36 https://doi.org/10.1002/jcp.1041490322
37 https://doi.org/10.1002/jcp.1041540325
38 https://doi.org/10.1006/excr.1993.1031
39 https://doi.org/10.1016/s0006-291x(05)81179-9
40 https://doi.org/10.1016/s0046-8177(87)80220-4
41 https://doi.org/10.1056/nejm198401193100307
42 https://doi.org/10.1073/pnas.76.10.5217
43 https://doi.org/10.1073/pnas.83.19.7297
44 https://doi.org/10.1073/pnas.83.7.2091
45 https://doi.org/10.1073/pnas.84.18.6471
46 https://doi.org/10.1073/pnas.87.17.6487
47 https://doi.org/10.1083/jcb.104.5.1403
48 https://doi.org/10.1083/jcb.107.3.1199
49 https://doi.org/10.1083/jcb.107.4.1589
50 https://doi.org/10.1083/jcb.108.2.671
51 https://doi.org/10.1083/jcb.109.2.811
52 https://doi.org/10.1083/jcb.109.2.823
53 https://doi.org/10.1083/jcb.109.2.877
54 https://doi.org/10.1083/jcb.111.2.731
55 https://doi.org/10.1083/jcb.97.5.1648
56 https://doi.org/10.1126/science.2425435
57 https://doi.org/10.1126/science.2821619
58 https://doi.org/10.1128/mcb.6.11.4060
59 https://doi.org/10.1172/jci111661
60 https://doi.org/10.1172/jci114322
61 schema:datePublished 1995-06
62 schema:datePublishedReg 1995-06-01
63 schema:description The effect of fibrin on angiogenesis in vitro was investigated using an experimental model of tube formation by bovine capillary endothelial cells (BCEs) in type I collagen gel. One milligram per milliliter of fibrin added into type I collagen gel significantly increased the length of the tubular structures formed by BCEs in the gel by about 180% compared with type I collagen only. The facilitating effect of fibrin on tube formation by BCEs was inhibited by either anti-basic fibroblast growth factor (bFGF) IgG (25 micrograms/ml) or anti-urokinase type plasminogen activator (uPA) IgG (10 micrograms/ml) added to the gel and culture medium, but not by anti-tissue type plasminogen activator (uPA) IgG (10 micrograms/ml) added to the gel and culture medium, but not by anti-tissue type plasminogen activator (10 micrograms/ml) or non-immune IgG. The Arg-Gly-Asp (RGD) containing peptides (100 micrograms/ml) added to the culture medium also suppressed tube formation by BCEs in fibrin-containing type I collagen gel, but not in type I collagen gel. These results suggest that the increased release of bFGF and uPA by BCEs therefore plays a role in the angiogenic effect of fibrin in vitro, and the angiogenic effect of fibrin is mediated by the RGD sequence in fibrin, probably via the function of integrin receptor of the BCEs.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf N99619cbe38414d1d80015819f5d4946e
68 Nc340ebdf165a42cfa02caaca90165be0
69 sg:journal.1312212
70 schema:name Effects of fibrin on the angiogenesis in vitro of bovine endothelial cells in collagen gel
71 schema:pagination 467-472
72 schema:productId N0c32daaf74604aa6954a142d252aecee
73 N22d8191c16204816aeec9b6a3b8f8280
74 N8a65be1014e443de840088887181cfa8
75 N9e7a2ad4be0846d7808bf55700d5f7d2
76 Neb9b08ec8f1d43cb8aa8e1cf88ef1532
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003126529
78 https://doi.org/10.1007/bf02634260
79 schema:sdDatePublished 2019-04-10T23:28
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher Nd5b6fc4a20b547beb7bcf2c63fe9b5dc
82 schema:url http://link.springer.com/10.1007%2FBF02634260
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N0c32daaf74604aa6954a142d252aecee schema:name pubmed_id
87 schema:value 8589891
88 rdf:type schema:PropertyValue
89 N1323cdfdb5c84f92b8bde0602e3ffbf7 rdf:first sg:person.0746243660.98
90 rdf:rest N7b0eff7baab54e289d199246672055c1
91 N22d8191c16204816aeec9b6a3b8f8280 schema:name dimensions_id
92 schema:value pub.1003126529
93 rdf:type schema:PropertyValue
94 N3f5ac2ac3c9f456e8c1597788599aa98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Immunoglobulin G
96 rdf:type schema:DefinedTerm
97 N4505477657634887abb6387d356388fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Animals
99 rdf:type schema:DefinedTerm
100 N600ad4fabf634848975b450f95fbb276 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Urokinase-Type Plasminogen Activator
102 rdf:type schema:DefinedTerm
103 N6b206f5fc20642dbb9f8e98568cf634d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Endothelium, Vascular
105 rdf:type schema:DefinedTerm
106 N7583b80e8d5644298186aa25a7277492 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Collagen
108 rdf:type schema:DefinedTerm
109 N7b0eff7baab54e289d199246672055c1 rdf:first sg:person.07456121032.01
110 rdf:rest Ncc0d26b43bf145c49b926d1fd5f0a3af
111 N88f7543ac1fb406ab53138d0a8fb7951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Structure-Activity Relationship
113 rdf:type schema:DefinedTerm
114 N8a65be1014e443de840088887181cfa8 schema:name nlm_unique_id
115 schema:value 9418515
116 rdf:type schema:PropertyValue
117 N99619cbe38414d1d80015819f5d4946e schema:issueNumber 6
118 rdf:type schema:PublicationIssue
119 N9e7a2ad4be0846d7808bf55700d5f7d2 schema:name doi
120 schema:value 10.1007/bf02634260
121 rdf:type schema:PropertyValue
122 N9f3ef284c7834f4e8308afddc748206c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Amino Acid Sequence
124 rdf:type schema:DefinedTerm
125 Nb81a94d4ad4f436fba9167a3df15f9da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cells, Cultured
127 rdf:type schema:DefinedTerm
128 Nc2dbbd6034574c369673b277e7f47837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cattle
130 rdf:type schema:DefinedTerm
131 Nc340ebdf165a42cfa02caaca90165be0 schema:volumeNumber 31
132 rdf:type schema:PublicationVolume
133 Nc4220b197ed34f0980d5bf705b26d069 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Gels
135 rdf:type schema:DefinedTerm
136 Ncc0d26b43bf145c49b926d1fd5f0a3af rdf:first sg:person.01232044316.84
137 rdf:rest rdf:nil
138 Nd15d8c1b016f4aaca4b8e3abe5e52fbf rdf:first sg:person.0730113326.97
139 rdf:rest N1323cdfdb5c84f92b8bde0602e3ffbf7
140 Nd5b6fc4a20b547beb7bcf2c63fe9b5dc schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Ndd45cc69ae61462080fc45dd8a98ccea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Fibroblast Growth Factor 2
144 rdf:type schema:DefinedTerm
145 Ne1f5e1a2eae84f50913b9fd8ccbd70f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Neovascularization, Pathologic
147 rdf:type schema:DefinedTerm
148 Neb9b08ec8f1d43cb8aa8e1cf88ef1532 schema:name readcube_id
149 schema:value 0ee49f45dd92ca2c94c18c1a7df65610dc72164e2bcca92a840202fefd705c34
150 rdf:type schema:PropertyValue
151 Nee85230399664a40830774c9d677ce12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Oligopeptides
153 rdf:type schema:DefinedTerm
154 Nfbd1b68db2c34c6282ba0bacc78cc759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Fibrin
156 rdf:type schema:DefinedTerm
157 Nfeab2c96566c4b14a6a3c03fca1b6e1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Molecular Sequence Data
159 rdf:type schema:DefinedTerm
160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biological Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biochemistry and Cell Biology
165 rdf:type schema:DefinedTerm
166 sg:journal.1312212 schema:issn 1071-2690
167 1543-706X
168 schema:name In Vitro Cellular & Developmental Biology - Animal
169 rdf:type schema:Periodical
170 sg:person.01232044316.84 schema:affiliation https://www.grid.ac/institutes/grid.177174.3
171 schema:familyName Sueishi
172 schema:givenName Katsuo
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232044316.84
174 rdf:type schema:Person
175 sg:person.0730113326.97 schema:affiliation https://www.grid.ac/institutes/grid.177174.3
176 schema:familyName Takei
177 schema:givenName Akira
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730113326.97
179 rdf:type schema:Person
180 sg:person.07456121032.01 schema:affiliation https://www.grid.ac/institutes/grid.177174.3
181 schema:familyName Nakashima
182 schema:givenName Yutaka
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456121032.01
184 rdf:type schema:Person
185 sg:person.0746243660.98 schema:affiliation https://www.grid.ac/institutes/grid.177174.3
186 schema:familyName Tashiro
187 schema:givenName Yoshihiko
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746243660.98
189 rdf:type schema:Person
190 sg:pub.10.1007/978-3-642-76849-1_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052568616
191 https://doi.org/10.1007/978-3-642-76849-1_2
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/bf00454828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051160805
194 https://doi.org/10.1007/bf00454828
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/bf02624102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013459818
197 https://doi.org/10.1007/bf02624102
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/bf02630933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009638448
200 https://doi.org/10.1007/bf02630933
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/288551a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048791001
203 https://doi.org/10.1038/288551a0
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/325257a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020191001
206 https://doi.org/10.1038/325257a0
207 rdf:type schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1075303632 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1077293455 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1077315966 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1078059855 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1078848552 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1078907766 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1078998519 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1079472265 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1081959973 schema:CreativeWork
217 https://doi.org/10.1002/jcp.1041250102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046651564
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/jcp.1041390317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038800108
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/jcp.1041490322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020898408
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/jcp.1041540325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008329490
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1006/excr.1993.1031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036708699
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0006-291x(05)81179-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003853862
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0046-8177(87)80220-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044926293
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1056/nejm198401193100307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037798000
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1073/pnas.76.10.5217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036710787
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1073/pnas.83.19.7297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017860011
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1073/pnas.83.7.2091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018736508
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.84.18.6471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017283198
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1073/pnas.87.17.6487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040685393
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1083/jcb.104.5.1403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046531044
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1083/jcb.107.3.1199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016369740
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1083/jcb.107.4.1589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005436877
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1083/jcb.108.2.671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018243257
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1083/jcb.109.2.811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011614714
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1083/jcb.109.2.823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035825260
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1083/jcb.109.2.877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040848050
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1083/jcb.111.2.731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044047535
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1083/jcb.97.5.1648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053711699
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1126/science.2425435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062537171
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1126/science.2821619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563620
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1128/mcb.6.11.4060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004289684
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1172/jci111661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053599406
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1172/jci114322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001130120
270 rdf:type schema:CreativeWork
271 https://www.grid.ac/institutes/grid.177174.3 schema:alternateName Kyushu University
272 schema:name First Department of Pathology, Faculty of Medicine, Kyushu University 60, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...