The effect of recombinant human basic fibroblast growth factor rhfgf-2 on human osteoblast in growth and phenotype expression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-10

AUTHORS

Saadia Berrada, Francoise Lefebvre, Marie-Francoise Harmand

ABSTRACT

This paper describes the studies of human recombinant basic fibroblast growth factor (rhFGF-2) for its effects on human osteoblast growth and phenotype expression. During a 24-h period of treatment, rhFGF-2 highly stimulated DNA synthesis in a dose-related fashion with a maximum stimulation of 150% for 1 ng/ml. On the other hand, rhFGF-2 decreases alkaline phosphatase activity, synthesis of type I collagen, and cumulative amount of osteocalcin. Moreover, rhFGF-2 provoked a threefold increase in the amount of intracellular cAMP. Scatchard plots show the presence of two classes of [125I] rhFGF-2 receptors. This data suggests that rhFGF-2 which stimulate cell replication may act indirectly as an anabolic agent and stimulate some of the phenotypic expression markers. More... »

PAGES

698-702

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02634091

DOI

http://dx.doi.org/10.1007/bf02634091

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010139278

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8564081


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