Human bone marrow stromal cells express an osteoblastic phenotype in culture View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

Joelle Vilamitjana-Amedee, Reine Bareille, Francois Rouais, Arnold I. Caplan, Marie-Francoise Harmand

ABSTRACT

This study reports the selection and characterization of osteogenic precursors from human bone marrow which were isolated by two “clonings” and successive subculturing. These cell lines express alkaline phosphatase activity. Gel electrophoresis of [3H]-proline labeled cultures showed that the cloned cells produce only type I collagen. They synthetize osteocalcin and osteonectin. They respond to 1,25 dihydroxy vitamin D3 by increasing osteocalcin synthesis and secretion, and to parathyroid hormone by increasing cyclic AMP synthesis. After the third subculture in the absence of β-glycerophosphate, these cell lines formed lots of clusters which exhibit high alkaline phosphatase activity and positive von Kossa staining. X-ray energy spectrum shows that these cells are surrounded by “budding” structures containing calcium and phosphorus with a ratio Ca:P identical to those of pure hydroxyapatite. This process was associated with45Ca uptake into the cells. All these data support the selection of osteogenic cells which may be of considerable clinical importance. More... »

PAGES

699-707

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02631426

DOI

http://dx.doi.org/10.1007/bf02631426

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015070143

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8407713


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