Decreased insulin binding to red blood cells in liver cirrhosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-07

AUTHORS

Aldo V. Greco, Aldo Bertoli, Salvatore Caputo, Lorenzo Altomonte, Raffaele Manna, Giovanni Ghirlanda

ABSTRACT

eleven male cirrhotic subjects, all with impaired glucose tolerance (IGT), were studied. Insulin binding to circulating erythrocytes was evaluated. The specific bound fraction was decreased compared to normals (5.95 +/-0.76 vs 7.08 +/- 0.84%; p less than 0.005). An negative correlation was found between fasting insulin and bound fraction (r = -0.68; p less than 0.05). We suggest that serum insulin may be chronically augmented as a consequence of liver damage. This induces a down-regulation of insulin receptors that is responsible for insulin resistance and at least in part for the impairment of glucose tolerance. More... »

PAGES

251-256

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02581269

DOI

http://dx.doi.org/10.1007/bf02581269

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025086797

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6356739


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