Local intraarterial thrombolysis: In vitro comparison between automatic and manual pulse-spray infusion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-11

AUTHORS

Jens J. Froelich, Christina Freymann, Martin Hoppe, Thomas Thiel, H. Joachim Wagner, Klemens H. Barth, Klaus J. Klose

ABSTRACT

PURPOSE: Manual and automatic pulse-spray infusion techniques are compared in vitro to evaluate the efficacy of thrombolysis and the distribution of urokinase and saline solution within thrombus using a pulse-spray catheter. METHODS: A pulse-spray catheter was introduced into a human thrombus within a stenotic flow model. Automatic and manual pulsed infusion of urokinase and automatic pulsed infusion of saline solution were compared. To quantify the efficacy of thrombolysis, pressure gradients were recorded proximal and distal to the thrombus and during the course of infusion. Distribution of infused urokinase was assessed radiographically. RESULTS: The fastest and most homogeneous dissolution of the thrombus was achieved with automatic pulsed infusion of urokinase, shown by decreasing transthrombotic pressure gradients (p < 0.001, Wilcoxon, matched pairs). Manual pulsed infusion of urokinase or saline solution resulted in inhomogeneous thrombus dissolution and delayed thrombolysis. CONCLUSION: Application of automatic pulse-spray injectors seems beneficial for more effective and homogeneous intraarterial pulse-spray thrombolysis when compared with conventional manual pulsed technique. More... »

PAGES

423-427

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02577631

DOI

http://dx.doi.org/10.1007/bf02577631

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052779768

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8994709


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