Technique and results of “low-dose” infusion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-01

AUTHORS

Barry T. Katzen

ABSTRACT

The results of 125 urokinase (UK) infusions in 108 patients were analyzed. Results showed total clot lysis in 61% of patients, partial lysis in 24%, and no lysis in 15%. Predictably, patients with acute occlusions had the highest incidence of complete clot lysis. However, clots older than 3 weeks had a surprisingly high lysis rate of 57%. None of the patients had a fibrinogen level below 100 mg/dL. Overall incidence of bleeding (major and minor) was 15%; patients having the most severe bleeding were on concomitant anticoagulation. We conclude that UK is a safe and effective therapeutic option in patients with acute and chronic obstruction. Significant bleeding episodes are uncommon during UK therapy and are related primarily to ongoing anticoagulation. More... »

PAGES

s39-s47

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02577096

DOI

http://dx.doi.org/10.1007/bf02577096

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015977350

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3131007


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