Assessment of new 6-Cl-HOBt based coupling reagents for peptide synthesis. Part 1: Coupling efficiency study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Giuseppina Sabatino, Barbara Mulinacci, Maria C. Alcaro, Mario Chelli, Paolo Rovero, Anna M. Papini

ABSTRACT

The efficiency of a series of well-known coupling reagents (TBTU, HATU, and PyBOP) and of newin situ activating reagents (TCTU, HCTU, and DMTMM) was compared by synthesizing the 65–74 fragment of the Acyl Carrier Protein (H-Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly-NH2), containing ‘a difficult sequence’, as a test peptide, in a multiple peptide synthesizer. The longer sequence rMOG(35–55) was also synthesized. It was clear that the aminium salts are more efficient than the phosphonium salt (PyBOP) and that the new 6Cl-HOBt based reagents (HCTU and particularly TCTU) are very efficient, while DMTMM appeared to be not suitable for SPPS. More... »

PAGES

119-123

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02576873

DOI

http://dx.doi.org/10.1007/bf02576873

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049388891


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