Hepatic artery infusion and chemoembolization in the management of liver metastases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

Sidney Wallace, C. Humberto Carrasco, Chusilp Charnsangavej, William R. Richli, Kenneth Wright, Cesare Gianturco

ABSTRACT

Hepatic metastases rather than the primary neoplasm usually dictate the course of the disease and the patient's survival. For unresectable disease, intraarterial infusion of chemotherapy, embolization, and chemoembolization are viable alternatives. Intraarterial therapy for hepatic metastases is based on the dual blood supply of the normal liver (portal vein, 75%, and hepatic artery, 25%) and that of the tumors (hepatic artery, 90%). Intraarterial infusion delivers a higher concentration of chemotherapy, whereas chemoembolization adds ischemia and increased contact time with the tumor. Selective vascular occlusion for infusion, redistribution of the blood supply and pulsatile flow enhance the delivery of therapeutic agents to the liver. More... »

PAGES

153-160

References to SciGraph publications

  • 1978-12. The blood supply of colorectal liver metastases in BRITISH JOURNAL OF CANCER
  • 1989. Chemoembolization of Liver Tumors in CANCER THERAPY
  • 1989-03. Transcatheter arterial embolization for metastatic liver tumors: A study in resected cases in CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02575467

    DOI

    http://dx.doi.org/10.1007/bf02575467

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042733039

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2121343


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